Results 21 to 30 of about 353,062 (253)

Sequential extraction and recognition of pulse group structure for multi‐function radar

IET Radar, Sonar & Navigation, 2022
The structure design and switching regulation of pulse groups in multi‐function radars (MFRs) are closely related to the work mode. The sequential extraction and recognition of MFR pulse group structure is a fundamental task to analysing and interpreting
Shi‐Qian Kang, Shuo Yuan, Cong Wang, Zhang‐Meng Liu   +3 more
doaj   +1 more source

Evolution of clinical trials: An overview on adaptive designs

Journal of Current Research in Scientific Medicine
Adaptive clinical trials are innovative study designs having flexibility and the ability to adapt its trial features and course for efficiency depending on the accumulating data from the trial itself.
Shanmugarajan Dayanidhi, Dharam Prasath
doaj   +1 more source

Choosing Interim Sample Sizes in Group Sequential Designs [PDF]

, 2021
This manuscript investigates sample sizes for interim analyses in group sequential designs. Traditional group sequential designs (GSD) rely on “information fraction” arguments to define the interim sample sizes. Then, interim maximum likelihood estimators (MLEs) are used to decide whether to stop early or continue the data collection until the next ...
Sergey S. Tarima, Nancy Flournoy
openaire   +3 more sources

Choice of futility boundaries for group sequential designs with two endpoints

BMC Medical Research Methodology, 2017
Background In clinical trials, the opportunity for an early stop during an interim analysis (either for efficacy or for futility) may relevantly save time and financial resources.
Svenja Schüler, Meinhard Kieser, Geraldine Rauch   +2 more
doaj   +1 more source

Accelerate vaccine development using seamless phase 2/3 trial designs

Expert Review of Vaccines
Background Traditional vaccine development, often a lengthy and costly process of three separated phases. However, the swift development of COVID-19 vaccines highlighted the critical importance of accelerating the approval of vaccines.
Jia-Ying Yang, Guo-Chun Li, Ying Yuan
doaj   +1 more source

Adaptive Clinical Trials and Sample Size Determination in the Presence of Measurement Error and Heterogeneity

Stats
Adaptive clinical trials offer a flexible approach for refining sample sizes during ongoing research to enhance their efficiency. This study delves into improving sample size recalculation through resampling techniques, employing measurement error and ...
Hassan Farooq, Sajid Ali, Ismail Shah, Ibrahim A. Nafisah, Mohammed M. A. Almazah   +4 more
doaj   +1 more source

Leg Mechanism Design and Motion Performance Analysis for an Amphibious Crab-like Robot

Journal of Marine Science and Engineering, 2023
Bionic-legged robots draw inspiration from animal locomotion methods and structures, demonstrating the potential to traverse irregular and unstructured environments.
Shihao Hu, Xinmeng Ma, Xi Chen, Mingfei Xin, Changda Tian, Kaixin Liu, Sicen Li, Liquan Wang, Qinyun Tang, Zhaojin Liu, Mingxuan Ding, Jiawei Li   +11 more
doaj   +1 more source

European Standard Clinical Practice Guideline and EXPeRT Recommendations for the Diagnosis and Management of Gastroenteropancreatic Neuroendocrine Neoplasms in Children and Adolescents

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Pediatric gastroenteropancreatic neuroendocrine neoplasms (GEP‐NENs) are extremely rare and clinically heterogeneous. Management has largely been extrapolated from adult practice. This European Standard Clinical Practice Guideline (ESCP), developed by the EXPeRT network in collaboration with adult NEN experts, provides (adult) evidence ...
Michaela Kuhlen, Calogero Virgone, Antje Redlich, Michael Abele, Ricardo Lopez‐Almaraz, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Maja Mazic Cesen, Andrea Ferrari, Malgorzata A. Krawczyk, Yves Reguerre, Dominik T. Schneider, Ines B. Brecht, Charlotte Rigaud, Bilgehan Yalcin, Rainer Claus, Christian Vokuhl, Constantin Lapa, Jörg Fuchs, Segolene Hescot, Thomas Walter, Julien Hadoux, Daniel Orbach   +23 more
wiley   +1 more source

GSD-SSR: an integrated framework for power analysis in IRB proposals using group sequential design and sample size re-estimation

Frontiers in Applied Mathematics and Statistics
Accurate sample size estimation is a cornerstone of successful Institutional Review Board (IRB) proposals, as it establishes the feasibility of clinical studies and ensures they are sufficiently powered to detect meaningful effects.
Yuxi Zhu, Yuxi Zhu, Shi Du, Peihe Xia, Peihe Xia   +4 more
doaj   +1 more source

Ovarian Sex Cord Stromal Tumors in Children and Adolescents—The European Standard Clinical Practice Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT As part of the European Cooperative Study Group for Paediatric Rare Tumours initiative, we developed standard clinical practice guidelines for ovarian sex cord stromal tumors, based on comprehensive national and international cohort analyses, literature review, and a final expert consensus conference.
Dominik T. Schneider, Kris‐Ann Schultz, Nora Schnitzler, Michael Abele, Tal Ben‐Ami, Ewa Bien, Gianni Bisogno, Ines B. Brecht, Maja Cesen, Andrea Ferrari, Michaela Kuhlen, Malgorzata A. Krawczyk, Ricardo Lopez‐Almaraz, Yves Reguerre, Calogero Virgone, Daniel Orbach   +15 more
wiley   +1 more source