Results 61 to 70 of about 353,062 (253)

Inference in group sequential designs with causal mechanisms: implications for power and mediation analysis

BMC Medical Research Methodology
Background Group sequential designs are increasingly employed to allow trials to stop early with statistical rigor. While existing work focuses on intention-to-treat effect on clinical endpoints, the properties of mediation analysis (commonly conducted ...
Kim May Lee, Richard Emsley
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Bayesian evaluation of group sequential clinical trial designs

Statistics in Medicine, 2006
AbstractClinical trial designs often incorporate a sequential stopping rule to serve as a guide in the early termination of a study. When choosing a particular stopping rule, it is most common to examine frequentist operating characteristics such as type I error, statistical power, and precision of confidence intervals (Statist. Med. 2005, in revision).
Scott S, Emerson, John M, Kittelson, Daniel L, Gillen   +2 more
openaire   +3 more sources

Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions

FEBS Letters, EarlyView.
The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang, Hyo Been Jin, Chang Min Kim, So Yeon Lee, Hyun Ho Park   +4 more
wiley   +1 more source

COMPARISON OF SIMULTANEOUS AND SEQUENTIAL REPAIR OF BILATERAL INGUINAL

Pakistan Armed Forces Medical Journal, 2009
Objective: Comparison of morbidity and short term complications of simultaneous bilateral inguinal hernia repair with sequential repair of bilateral inguinal hernia. Study Design: Quasi-experimental study.
Rana Hassan Javed, Nauman Anwar Rana, Asma Afzal Kiani, Ahmed Waqas   +3 more
doaj   +2 more sources

Sequential endoscopic treatment for esophageal and gastric variceal bleeding significantly reduces patient mortality and rebleeding rates

Therapeutic Advances in Gastroenterology
Background: Esophageal-gastric variceal bleeding (EGVB) is a serious complication in patients with liver cirrhosis, characterized by high mortality and rebleeding rates.
Kong Tao, Xu Shan, Binbo He, Qingyu Zeng, Meirong Wu, Liu Jie, Wenfeng Yuan, Hu Dan, Zhang Tao   +8 more
doaj   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Practical and analytical considerations when performing interim analyses in diagnostic test accuracy studies

Diagnostic and Prognostic Research
Interim analysis is a common methodology in randomised clinical trials but has received less attention in studies of diagnostic test accuracy. In such studies, early termination for futility may be beneficial if early evidence indicates that a diagnostic
Susannah Fleming, Lazaro Mwandigha, Thomas R. Fanshawe   +2 more
doaj   +1 more source

Drilling down to success: Comparative insight on single-drill and sequential-drill techniques for dental implant osseointegration using osteoprotegerin levels - A randomized control trial

Journal of Oral Biology and Craniofacial Research
Background: To evaluate and compare osteoblastic activity and osseointegration between single-drill and sequential-drill implant site preparation techniques, using osteoprotegerin (OPG) levels as a biomarker. Methods: A randomized controlled trial with a
Jerome Rahul James, Karthigeyan Jeyapalan, Shanmuganathan Natarajan   +2 more
doaj   +1 more source

A Bayesian group sequential design for randomized biosimilar clinical trials with adaptive information borrowing from historical data. [PDF]

J Biopharm Stat, 2022
Zhang W, Pan Z, Yuan Y.
europepmc   +1 more source