Results 61 to 70 of about 375,287 (267)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

New solution scheme for the member revocation in group signature

Tongxin xuebao, 2014
In order to solve the problem that Camenisch-Stadler's group signature scheme could not revoke members,a new revocation scheme based on the Camenisch-Stadler's group scheme was proposed,allowing the group manager to add new members or revoke old members ...
De-dong ZHANG, Zhao-feng MA, Yi-xian YANG, Xin-xin NIU   +3 more
doaj  

Investigating transcription factor dynamics in health and disease using FRAP

FEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj, Carolina Vazquez Garzon, Jose Joaquin Velasco, Janine N. Post   +3 more
wiley   +1 more source

Convertible Group Undeniable Signatures [PDF]

, 2003
Group undeniable signatures are like ordinary group signatures except that verifying signatures needs the help of the group manager. In this paper, we propose a convertible group undeniable signature scheme in which the group manager can turn all or selective signatures, which are originally group undeniable signatures, into ordinary group signatures ...
Lyuu, Yuh-Dauh, Wu, Ming-Luen
openaire   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Lattice based signatures with additional functionalities [PDF]

Surveys in Mathematics and its Applications
A digital signature is a cryptographic protocol that can provide added assurances of an electronic document's identity, status, and proof of origin and acknowledge informed consent by the signer. Lattice-based assumptions have seen a rush in recent years
Swati Rawal, Sahadeo Padhye, Ramakant Kumar, Debiao He   +3 more
doaj  

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

CHAT: Cross-Metaverse Heterogeneous Domain Authentication with Traceability

Applied Sciences
As the metaverse evolves toward a large-scale multi-domain ecosystem, in which different domains may rely on different trust models, avatar cross-metaverse access increasingly depends on prior authentication between heterogeneous domains.
Chenxi Wu, Hongfeng Gao, Youliang Tian, Kun Niu, Axin Xiang   +4 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Efficient group signature scheme with revocation

Tongxin xuebao, 2016
A group signature scheme which combines the subset cover framework with Camenisch-Stadler scheme was proposed.This scheme allowed any group members’ entrance and revocation without changing other members’ secret key.Meanwhile,the scheme added a knowledge
Hong ZHONG, Cong-lin HUANG, Yan XU, Jie CUI   +3 more
doaj   +2 more sources