Results 131 to 140 of about 18,357,901 (314)

Antea Group Archeologie 2018/8

, 2018
In november/december 2017 (Haven 8-West) en februari 2018 (Haven 8-Oost) is door Antea Group in opdracht van de gemeente Waalwijk een inventariserend veldonderzoek, met proefsleuven. Dit voor het plangebied Haven 8 te Waalwijk.
Koopmanschap, Dr. H.J.L.C. (Antea Group)
core   +1 more source

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics

FEBS Letters, EarlyView.
Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt, Ana‐Maria Sandru, Georg Vucak, Sebastian Didusch, Biljana Riemelmoser, Karin Ehrenreiter, Markus Hartl, Lukas A. Huber, Manuela Baccarini   +8 more
wiley   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

Antea Group Archeologie 2019/125

, 2020
Antea Projectnummer 436792. In april 2019 heeft Antea Group Archoelogie een archeologisch veldonderzoek (Opgraving, variant archeologische begeleiding) uitgevoerd op een locatie langs de Oosterweg te Pieterburen (afb. 1). Aanleiding is de aanleg van een
Tuinstra, S.J. (Antea Group), Sibma, T. (Antea Group)   +1 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Reconstruction of 3D Conductive Networks in Metal‐Filled Elastomer Composites Indicates Dominance of Contact Resistances

Small Structures
Conductive polymer composites (CPCs) combine the stretchability of an elastomeric matrix with the electrical conductivity of a metallic filler. The 3D structure of this filler particle network (FPN) and the contact resistances between particles above ...
Dominik Perius, Michael Engstler, Simon Blum, Lola González‐García, Tobias Kraus   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Anion and Cation Co-Doping of NiO for Transparent Photovoltaics and Smart Window Applications

Crystals
Materials engineering based on metal oxides for manipulating the solar spectrum and producing solar energy have been under intense investigation over the last years.
Chrysa Aivalioti, Emmanouil G. Manidakis, Nikolaos T. Pelekanos, Maria Androulidaki, Katerina Tsagaraki, Elias Aperathitis   +5 more
doaj   +1 more source