Results 141 to 150 of about 18,357,901 (314)

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Design and Performance of Solvent-Based Regenerated Cold Feed for Fine Screening

Zhongwai Gonglu
To overcome the limitations of evaluation methods for the performance of cold patching asphalt mixtures, this paper systematically studied the pavement performance and its evaluation system of solvent-based cold patching asphalt mixtures using fully ...
YAN Chunpeng, ZHU Yaoting, FAN Xiangyang, LIU Bin, YI Zhao   +4 more
doaj   +1 more source

Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry

FEBS Letters, EarlyView.
EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri, Ayaka Nagasato‐Ichikawa, Keita Iida, Shuhei Kimura, Akira Imamoto, Mariko Okada   +5 more
wiley   +1 more source

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

The effect of particles on static crystallisation in suspensions: sucrose vs inulin

npj Science of Food
The crystallisation of lipids in suspensions is influenced by the presence of the suspended material, in contrast to crystallisation in bulk lipids. In this research, the impact of carbohydrate particles on the crystallisation of palm oil was studied ...
Fien De Witte, Ivana A. Penagos, Davy Van de Walle, Andre G. Skirtach, Filip Van Bockstaele, Koen Dewettinck   +5 more
doaj   +1 more source

Antea Group Archeologie 2017/26

, 2017
Het plangebied doorkruist het dekzandlandschap van Oosterhout en Dongen. Archeologische resten kunnen dateren vanaf de ijzertijd tot en met de nieuwe tijd, hoewel de hoogte verwachting geldt voor de perioden ijzertijd, (late) middeleeuwen en nieuwe tijd.
Colijn, MA J.E. (Antea Group)
core   +1 more source

Translophagy—A potential link between autophagy impairment and translational errors

FEBS Letters, EarlyView.
Neurodegenerative diseases are characterised by the accumulation of abnormal proteins and protein aggregates, but their origin often remains unknown. We propose that selective autophagy removes damaged protein‐making machinery, preventing errors during protein synthesis.
Mykola V. Korolchuk, Gailing Ma, Robin Antrobus, Diego Manni, Marco Trevisan‐Herraz, Mustafa Khwaja, Max Brown, Gavin D. Richardson, Masaaki Komatsu, Daniel Erskine, Viktor I. Korolchuk, Tetsushi Kataura   +11 more
wiley   +1 more source

Bonding Durability Evaluation of Polymer-Modified Emulsified Asphalt Microsurfacing

Advances in Materials Science and Engineering
At present, there are few research studies on the durability of microsurfacing. To further improve the service quality and durability of microsurfacing, five kinds of polymer-modified emulsified asphalt were used to prepare microsurfacing mixture.
Hao Fu, Qian Chen, Xiaolong Sun, Wenwu Zhang, Shanshan Wang   +4 more
doaj   +1 more source

Mono- and Mixed Metal Complexes of Eu³⁺, Gd³⁺, and Tb³⁺ with a Diketone, Bearing Pyrazole Moiety and CHF₂-Group: Structure, Color Tuning, and Kinetics of Energy Transfer between Lanthanide Ions. [PDF]

Molecules, 2021
Gontcharenko VE, Kiskin MA, Dolzhenko VD, Korshunov VM, Taydakov IV, Belousov YA.   +5 more
europepmc   +1 more source

Structural and biochemical analysis of a B12 superbinder

FEBS Letters, EarlyView.
BtuG proteins are vitamin B12 scavengers in Bacteroides thetaiotaomicron, a dominant human gut bacterium. We present crystal structures of three BtuG homologs bound to cobalamin and its precursor cobinamide, revealing picomolar binding affinities, among the highest known for any natural protein.
Jose M. Martinez Felices, Jacob J. Whittaker, Dirk J. Slotboom, Albert Guskov   +3 more
wiley   +1 more source