Results 81 to 90 of about 2,901,133 (217)

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

The effect of particles on static crystallisation in suspensions: sucrose vs inulin

npj Science of Food
The crystallisation of lipids in suspensions is influenced by the presence of the suspended material, in contrast to crystallisation in bulk lipids. In this research, the impact of carbohydrate particles on the crystallisation of palm oil was studied ...
Fien De Witte, Ivana A. Penagos, Davy Van de Walle, Andre G. Skirtach, Filip Van Bockstaele, Koen Dewettinck   +5 more
doaj   +1 more source

Mono- and Mixed Metal Complexes of Eu³⁺, Gd³⁺, and Tb³⁺ with a Diketone, Bearing Pyrazole Moiety and CHF₂-Group: Structure, Color Tuning, and Kinetics of Energy Transfer between Lanthanide Ions. [PDF]

Molecules, 2021
Gontcharenko VE, Kiskin MA, Dolzhenko VD, Korshunov VM, Taydakov IV, Belousov YA.   +5 more
europepmc   +1 more source

The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers

Molecular Oncology, EarlyView.
The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce, Simone Bini, Marialuisa Sponziello, Giorgio Grani, Giulia Fiscon, Paola Paci, Lorenzo Farina, Rosa Falcone, Valentina Maggisano, Sebastiano Filetti, Cosimo Durante, Antonella Verrienti   +11 more
wiley   +1 more source

Bonding Durability Evaluation of Polymer-Modified Emulsified Asphalt Microsurfacing

Advances in Materials Science and Engineering
At present, there are few research studies on the durability of microsurfacing. To further improve the service quality and durability of microsurfacing, five kinds of polymer-modified emulsified asphalt were used to prepare microsurfacing mixture.
Hao Fu, Qian Chen, Xiaolong Sun, Wenwu Zhang, Shanshan Wang   +4 more
doaj   +1 more source

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The Effect of Nitrogen as a Co-Dopant in p-Type NiO:Nb Films on the Photovoltaic Performance of NiO/TiO₂ Transparent Solar Cells

Solids
Doping engineering has been applied in niobium-doped NiO (NiO:Nb) by adding nitrogen (N) in its structure. The rf-sputtered films were made from a Ni-Nb composite target on unheated substrates at 300 W rf power and 5 mTorr total pressure.
Chrysa Aivalioti, Maria Androulidaki, Katerina Tsagaraki, Emmanouil G. Manidakis, Charidimos Koliakoudakis, Nikolaos T. Pelekanos, Mircea Modreanu, Elias Aperathitis   +7 more
doaj   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Effect of Shear on Polymorphic Transitions in Monoglyceride Oleogels

Crystals
Fat polymorphism plays a critical role in the structural and functional properties of fat-based food products. However, research on the polymorphism of monoglyceride oleogels remains limited.
Kato Rondou, Fien De Witte, Koen Dewettinck, Filip Van Bockstaele   +3 more
doaj   +1 more source

Network divergence analysis identifies adaptive gene modules and two orthogonal vulnerability axes in pancreatic cancer

Molecular Oncology, EarlyView.
Tumors contain diverse cellular states whose behavior is shaped by context‐dependent gene coordination. By comparing gene–gene relationships across biological contexts, we identify adaptive transcriptional modules that reorganize into distinct vulnerability axes.
Brian Nelson, Lyanne Delgado‐Coka, Natalia Marchenko, Luisa F. Escobar‐Hoyos, Kenneth R. Shroyer, Alisa Yurovsky, Trey Ideker, Gábor Balázsi, Thomas MacCarthy, Scott Powers   +9 more
wiley   +1 more source