Results 91 to 100 of about 1,525,569 (308)
CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3
Molecular Oncology, EarlyView.PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh +12 more
wiley +1 more source
E2A selectively regulates TGF‐β–induced apoptosis in KRAS‐mutant non‐small cell lung cancer
Molecular Oncology, EarlyView.Ability to induce apoptosis by TGF‐β is frequently lost in advanced lung adenocarcinoma despite intact TGF‐β signaling. We identify E2A as a mutant KRAS–dependent mediator of resistance to TGF‐β–induced apoptosis. TGF‐β induces E2A via SMAD3 in mutant KRAS cells, and E2A silencing restores apoptosis and enhances radiation response in cell lines ...
Sergei Chuikov +3 more
wiley +1 more source
Grupphandledning I psykoterapi inom ramen för utbildningar
, 2005 The focus of this paper is group supervision in psychotherapy training. Results emanating from studies performed in collaboration between a number of Swedish universities and university affiliated training units are summarized.
Boalt Boëthius, S +2 more
core
How does the supervision stringency affect systemic risk based on the differential dynamic model?
Systems Science & Control Engineering, 2019 This paper focused on the supervision stringency and studied its impact on the financial system risk contagion mechanism. This paper adopts Susceptible-Exposed-Infected-Recovered epidemical model and sets supervision stringency as the principal parameter.
Bian Chenyu, Yang Haomiao, Zhang Ning
doaj +1 more source
Molecular Oncology, EarlyView.Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau +8 more
wiley +1 more source
Integrated Financial Supervision in Germany [PDF]
With the establishment of the Bundesanstalt für Finanzdienstleistungsaufsicht (BaFin) in May 2002 Germany followed the trend towards integrated financial supervision.
Schüler, Martin
core
Group versus individual supervision of university students: a qualitative study
Dansk Universitetspaedagogisk Tidsskrift, 2019 Background: Studies investigating strengths and limitations of group and individual supervision of university students are sparse. The aims of the present study were to investigate advantages and disadvantages of group and individual supervision, and to ...
janni Niclasen, Pernille Strøbæk
doaj
BMC NursingBackground Providing positive and supportive environments for nurses and midwives working in ever-changing and complex healthcare services is paramount.
Owen Doody +4 more
doaj +1 more source
KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer
Molecular Oncology, EarlyView.Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan +16 more
wiley +1 more source
Molecular Oncology, EarlyView.We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu +10 more
wiley +1 more source