Results 111 to 120 of about 1,525,569 (308)

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

open access: yesMolecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata   +10 more
wiley   +1 more source

Practice supervision [PDF]

open access: yes
This second chapter starts with the key requirements for the welcoming of students and apprentices as newcomers to the practice environment from the perspective of promoting a sense of belongingness.
Sharples, A, Wareing, M
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

open access: yesMolecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary   +1 more
wiley   +1 more source

Supervision of interpreters – a Norwegian study

open access: yes, 2017
Die vorliegende Untersuchung will die Notwendigkeit eines Supervisionsangebotes für Dolmetscher, die mit Flüchtlingen und Einwanderern in Norwegen arbeiten, begründen.
Petzold, Hilarion G.   +2 more
core   +1 more source

Clinical performance of the urine‐based TERT promoter AbsoluteQ Digital PCR for non‐invasive detection of bladder cancer

open access: yesMolecular Oncology, EarlyView.
A urine‐based digital PCR assay targeting two hotspot TERT promoter variants detected bladder cancer with high sensitivity and no false positives in this case–control cohort. The streamlined AbsoluteQ workflow outperformed Sanger sequencing and supports non‐invasive molecular testing for bladder cancer detection.
Anna Nykel   +12 more
wiley   +1 more source

A Stigler View on Banking Supervision [PDF]

open access: yes
The system of banking supervision in Europe is undergoing substantial reforms. According to Stigler?s capture theory regulation often follows the preferences of producers.
Heinemann, Friedrich, Schüler, Martin
core  

Developmental programmes drive cellular plasticity, disease progression and therapy resistance in lung adenocarcinoma

open access: yesMolecular Oncology, EarlyView.
This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska   +13 more
wiley   +1 more source

Group supervision: topics, process and outcome

open access: yes, 2009
Supervision has been defined as “a formal process of professional support and learning which enables individual practitioners to develop knowledge and competence, assume responsibility for their own practice and enhance consumer protection and safety ...
GIUNTA, Serena   +6 more
core  

Evaluation and prediction of coal seam mining mode: Coefficient of Variation-TOPSIS and CNN-NGO methods

open access: yesAIP Advances
Selecting the appropriate method for coal seam mining is the foremost task for the safe and efficient production of coal mines. This study explores and validates an integrated evaluation system that enhances the accuracy of predicting coal seam mining ...
Haixiong Li, Fei Wang
doaj   +1 more source

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