Results 61 to 70 of about 897,561 (319)
Groups definable in simple theories retain the chain conditions and decomposition properties known from stable groups, up to commensurability. In the small case, if a generic type of G is not foreign to some type q, there is a q-internal quotient. In the supersimple case, the Berline-Lascar decomposition works.
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Antimicrobial resistance (AMR) is of huge importance, resulting in over 1 million deaths each year. Here, we describe how a new drug, enmetazobactam, designed to help fight resistant bacterial diseases, inhibits a key enzyme (GES‐1) responsible for AMR. Our data show it is a more potent inhibitor than the related tazobactam, with high‐level computation
Michael Beer +10 more
wiley +1 more source
Calogero-Sutherland approach to defect blocks
Extended objects such as line or surface operators, interfaces or boundaries play an important role in conformal field theory. Here we propose a systematic approach to the relevant conformal blocks which are argued to coincide with the wave functions of ...
Mikhail Isachenkov +3 more
doaj +1 more source
Single‐cell RNA sequencing reveals an opposite role of SLPI in basal tumors based on metastatic spread, along with shared activation of specific regulons in cancer cells and mature luminal lactocytes, as well as downregulation of MALAT1 and NEAT1 in the latter.
Pietro Ancona +4 more
wiley +1 more source
Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
wiley +1 more source
Four-loop non-singlet splitting functions in the planar limit and beyond
We present the next-to-next-to-next-to-leading order (N3LO) contributions to the non-singlet splitting functions for both parton distribution and fragmentation functions in perturbative QCD. The exact expressions are derived for the terms contributing in
S. Moch +4 more
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On the Groups with Homogeneous Theory
If \(2\leq m < n\) then a structure \(M\) is \((m,n)\)-homogeneous if for any \(\bar{a},\bar{b} \in M^n\), \(\bar{a}\) and \(\bar{b}\) have the same type if and only if corresponding \(m\)-subtuples have the same type. A complete theory is \((m,n)\)-homogeneous if all its subtuples are.
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Covering group theory for compact groups
In the paper, a homomorphism between topological groups is assumed continuous. All topological groups are Hausdorff. The authors and \textit{C. Stallman} have introduced in [Trans. Am. Math. Soc. 351, 1403-1422 (1999; Zbl 0909.22007)] the following notion: Let \(G, H\) be topological groups.
Valerii N. Berestovskii, Conrad Plaut
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Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
wiley +1 more source
On holographic entanglement entropy of Horndeski black holes
We study entanglement entropy in a particular tensor-scalar theory: Horndeski gravity. Our goal is two-fold: investigate the Lewkowycz-Maldacena proposal for entanglement entropy in the presence of a tensor-scalar coupling and address a puzzle existing ...
Elena Caceres +2 more
doaj +1 more source

