Results 71 to 80 of about 6,247,235 (281)
FEBS Letters, EarlyView.Mitochondrial remodeling shapes neural and glial lineage progression by matching metabolic supply with demand. Elevated OXPHOS supports differentiation and myelin formation, while myelin compaction lowers mitochondrial dependence, revealing mitochondria as key drivers of developmental energy adaptation.
Sahitya Ranjan Biswas +3 more
wiley +1 more source
The ubiquitin ligase RNF115 is required for the clearance of damaged lysosomes
FEBS Letters, EarlyView.Upon lysosomal rupture, an E3 ubiquitin ligase RNF115 translocates from the cytosol to the damaged lysosomal membrane. Moreover, RNF115 depletion impairs the clearance of damaged lysosomes, identifying it as a key regulator of lysosomal quality control.
Sae Nakanaga +3 more
wiley +1 more source
, 2005 Groups definable in simple theories retain the chain conditions and decomposition properties known from stable groups, up to commensurability. In the small case, if a generic type of G is not foreign to some type q, there is a q-internal quotient. In the supersimple case, the Berline-Lascar decomposition works.
openaire +2 more sources
Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Calogero-Sutherland approach to defect blocks
Journal of High Energy Physics, 2018 Extended objects such as line or surface operators, interfaces or boundaries play an important role in conformal field theory. Here we propose a systematic approach to the relevant conformal blocks which are argued to coincide with the wave functions of ...
Mikhail Isachenkov +3 more
doaj +1 more source
, 2015 The notion of almost centralizer and almost commutator are introduced and basic properties are established. They are used to study $\widetilde{\mathfrak M}\_c$-groups, i.
Hempel, Nadja
core +1 more source
Renormalization Group Theory for Global Asymptotic Analysis
, 1994 We show with several examples that renormalization group (RG) theory can be used to understand singular and reductive perturbation methods in a unified fashion.
A. C. Newell +22 more
core +2 more sources
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Four-loop non-singlet splitting functions in the planar limit and beyond
Journal of High Energy Physics, 2017 We present the next-to-next-to-next-to-leading order (N3LO) contributions to the non-singlet splitting functions for both parton distribution and fragmentation functions in perturbative QCD. The exact expressions are derived for the terms contributing in
S. Moch +4 more
doaj +1 more source