Results 91 to 100 of about 6,247,235 (281)

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Structural measures of personal networks predict migrants' cultural backgrounds: an explanation from Grid/Group theory. [PDF]

PNAS Nexus, 2022
Molina JL, Ozaita J, Tamarit I, Sánchez A, McCarty C, Bernard HR.   +5 more
europepmc   +1 more source

Dammarenediol II enhances etoposide‐induced apoptosis by targeting O‐GlcNAc transferase and Akt/GSK3β/mTOR signaling in liver cancer

Molecular Oncology, EarlyView.
Etoposide induces DNA damage, activating p53‐dependent apoptosis via caspase‐3/7, which cleaves PARP1. Dammarenediol II enhances this apoptotic pathway by suppressing O‐GlcNAc transferase activity, further decreasing O‐GlcNAcylation. The reduction in O‐GlcNAc levels boosts p53‐driven apoptosis and influences the Akt/GSK3β/mTOR signaling pathway ...
Jaehoon Lee, Byung‐Cheol Han, Gi‐Bang Koo, Jihye Park, Mijin Kwon, Young Bin Park, Jae‐Mun Choi, Seung‐Ho Lee, Sangho Roh   +8 more
wiley   +1 more source

Renormalization group theory of molecular dynamics. [PDF]

Sci Rep, 2021
Ichishima D, Matsumura Y.
europepmc   +1 more source

Representation Theory of Twisted Group Double

, 2003
This text collects useful results concerning the quasi-Hopf algebra $\D $. We give a review of issues related to its use in conformal theories and physical mathematics.
Altschuler, D., Coste, A., Maillard, J-M.   +2 more
core   +3 more sources

Tumor mutational burden as a determinant of metastatic dissemination patterns

Molecular Oncology, EarlyView.
This study performed a comprehensive analysis of genomic data to elucidate whether metastasis in certain organs share genetic characteristics regardless of cancer type. No robust mutational patterns were identified across different metastatic locations and cancer types.
Eduardo Candeal, Andrea Moreno‐Manuel, Miguel Salvadó‐Pertierra, Cristina Santos‐Vivas, Rebeca Sanz‐Pamplona   +4 more
wiley   +1 more source

Electroweak baryogenesis and the standard model effective field theory

Journal of High Energy Physics, 2018
We investigate electroweak baryogenesis within the framework of the Standard Model Effective Field Theory. The Standard Model Lagrangian is supplemented by dimension-six operators that facilitate a strong first-order electroweak phase transition and ...
Jordy de Vries, Marieke Postma, Jorinde van de Vis, Graham White   +3 more
doaj   +1 more source

State-space renormalization group theory of nonequilibrium reaction networks: Exact solutions for hypercubic lattices in arbitrary dimensions. [PDF]

Phys Rev E, 2022
Yu Q, Tu Y.
europepmc   +1 more source

Correlation of the differential expression of PIK3R1 and its spliced variant, p55α, in pan‐cancer

Molecular Oncology, EarlyView.
PIK3R1 undergoes alternative splicing to generate the isoforms, p85α and p55α. By combining large patient datasets with laboratory experiments, we show that PIK3R1 spliced variants shape cancer behavior. While tumors lose the protective p85α isoform, p55α is overexpressed, changes linked to poorer survival and more pronounced in African American ...
Ishita Gupta, Yang Song, Madeleine Ndahayo, Anirudh Saxena, Theresa Guo, Dylan Z. Kelley, Jessica Gore, Andrew Hennigan, Alexa Anderson, John C. Papadimitriou, Daria A. Gaykalova   +10 more
wiley   +1 more source

Group Theory Analysis to Study Phase Transitions of Quasi-2D Sr₃Hf₂O₇. [PDF]

Nanomaterials (Basel), 2021
da Silva EL, Gerami AM, Lekshmi PN, Marcondes ML, Assali LVC, Petrilli HM, Correia JG, Lopes AML, Araújo JP.   +8 more
europepmc   +1 more source