Results 131 to 140 of about 4,740,639 (302)
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Evaluation of the Systemic and Regional Antibiotic Therapy Effectiveness as Part of Complex Therapy in Patients with Locally Spread Breast Cancer [PDF]
, 2019 In recent years, breast cancer is the most common oncologic pathology and the most common cause of disability among women in developed countries.The aim of the study.
Bondar, O. (Oleksandr)
core
Effective therapeutic targeting of CTNNB1‐mutant hepatoblastoma with WNTinib
Molecular Oncology, EarlyView.WNTinib, a Wnt/CTNNB1 inhibitor, was tested in hepatoblastoma (HB) experimental models. It delayed tumor growth and improved survival in CTNNB1‐mutant in vivo models. In organoids, WNTinib outperformed cisplatin and showed enhanced efficacy in combination therapy, supporting its potential as a targeted treatment for CTNNB1‐mutated HB.
Ugne Balaseviciute +17 more
wiley +1 more source
Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Taḥqīqāt-i ̒Ulūm-i Raftārī, 2017 Aim and Background: A reason for the higher prevalence of psychological problems in individuals with obesity is their lack of emotional control. The aim of this study was the assessment of the effectiveness of emotion regulation techniques on the ...
آسیه کریمی +2 more
doaj
Social SciencesTreatment preferences are an important part of evidence-based practice and have been shown to affect treatment outcomes. In this two-part study, incarcerated women were asked about their preferences for two versions of a trauma-focused group treatment ...
Marie E. Karlsson +2 more
doaj +1 more source
Post-inpatient Attrition from Care “As Usual” in Veterans with Multiple Psychiatric Admissions [PDF]
, 2013 Disengagement from outpatient care following psychiatric hospitalization is common in high-utilizing psychiatric patients and contributes to intensive care utilization.
Berger, Bertrand +2 more
core +1 more source
Molecular Oncology, EarlyView.Monitoring circulating tumor DNA (ctDNA) in patients with operable breast cancer can reveal disease relapse earlier than radiology in a subset of patients. The failure to detect ctDNA in some patients with recurrent disease suggests that ctDNA could serve as a supplement to other monitoring approaches.
Kristin Løge Aanestad +35 more
wiley +1 more source
Taḥqīqāt-i ̒Ulūm-i Raftārī, 2017 Aim and Background: Addiction and its unpleasant consequences are one of the most important public health problems worldwide. Initial maladaptive schemas are related to addiction.
مهران روزبهی +2 more
doaj
DisabilitiesBackground: Mental illnesses are pervasive amongst children and adolescents with intellectual disabilities (ID), particularly anxiety disorders. To date, there has been limited research on the use of cognitive behavior therapy (CBT) as a potential ...
Chloe Harrington, Anastasia Hronis
doaj +1 more source