Results 81 to 90 of about 16,466,590 (349)
Interpreting the effects of DNA polymerase variants at the structural level
Molecular Oncology, EarlyView.Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi +7 more
wiley +1 more source
The Role of Infill Density in Impact Localization for Additively Manufactured Structures
SensorsThe optimization of impact localization in 3D-printed structures is critical for their application in smart monitoring and damage detection systems.
Hussain Altammar
doaj +1 more source
Calculation of Guided Wave Dispersion Characteristics Using a Three-Transducer Measurement System
Applied Sciences, 2018 Guided ultrasonic waves are of significant interest in the health monitoring of thin structures, and dispersion curves are important tools in the deployment of any guided wave application.
Borja Hernandez Crespo +2 more
doaj +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source
Group-velocity dispersion engineering of tantala integrated photonics
, 2020 Designing integrated photonics, especially to leverage Kerr-nonlinear optics, requires accurate and precise knowledge of refractive index across the visible to infrared spectral ranges.
Richelle Streater (9675608) +5 more
core +1 more source
Negative group velocity characteristics of spoof surface plasmon polaritons
AIP Advances, 2023 Although there have been many discussions on negative group velocity (NGV), disagreements over its counter-intuitive explanations are still on the way. In this paper, it is proposed that the negative group velocity is just a component of the actual wave ...
Jun Lei +4 more
doaj +1 more source
, 2011 The response to wave forcing of finite duration comprises a transient forerunner and the steady state signal (or simply the signal). It is the latter that carries information on the spectral content of the forcing, and the signal velocity is the velocity
R. Walterscheid, M. Hickey
semanticscholar +3 more sources
Molecular Oncology, EarlyView.Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski +12 more
wiley +1 more source
Negative group velocity of surface plasmons on thin metallic films
, 2006 By tailoring the dispersion curve of surface plasmons (SPs) of a thin metallic film surrounded by dielectric half-spaces, it is shown that the group velocity of the symmetric mode is always positive, while the group velocity of the anti-symmetric mode ...
Liu, Yongmin +11 more
core +1 more source
HALO VELOCITY GROUPS IN THE PISCES OVERDENSITY [PDF]
The Astrophysical Journal, 2010 21 pages, 5 figures, 3 tables, accepted to Astrophysical ...
Sesar, Branimir +3 more
openaire +2 more sources