Results 41 to 50 of about 35,426 (265)

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Kerr nonlinearity and group velocity dispersion of InGaAs/InP and GaAsSb/InP waveguides in the mid-infrared

open access: yesAPL Photonics, 2023
We report measurements of Kerr nonlinearity and group velocity dispersion in In0.53Ga0.47As/InP and GaAs0.51Sb0.49/InP ridge waveguides in the mid-infrared using four-wave mixing at λ ≈ 5 µm.
Kevin Zhang   +2 more
doaj   +1 more source

ADP‐ribosylation: An emerging regulator of the epigenome

open access: yesMolecular Oncology, EarlyView.
ADP‐ribosylation has emerged as a dynamic epigenetic signaling mechanism that modifies histones and chromatin‐associated proteins. Through coordinated PARylation and MARylation, it integrates with other histone modifications to regulate chromatin structure, transcription factor activity, and gene expression, influencing genome function and disease ...
Cristel V. Camacho   +2 more
wiley   +1 more source

Confirmation of an Anomalously Low Dark Matter Content for the Galaxy NGC 1052-DF4 from Deep, High-resolution Continuum Spectroscopy

open access: yesThe Astrophysical Journal, 2023
NGC 1052-DF4 was found to be the second “galaxy lacking dark matter” in the NGC 1052 group, based on its velocity dispersion of ${\sigma }_{\mathrm{gc}}={4.2}_{-2.2}^{+4.4}$ km s ^−1 as measured from the radial velocities of seven of its globular ...
Zili Shen   +2 more
doaj   +1 more source

Galaxy groups: abundance by luminosity and by velocity dispersion [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society, 1993
We present a reanalysis of groups in the Center for Astrophysics redshift survey, focusing on properties that can be readily compared with predictions of gravitational clustering theories. The grouping algorithm we employ is optimized using artificial catalogues constructed from N-body simulations that have similar low-order correlations to those of ...
B. Moore, C. S. Frenk, S. D. M. White
openaire   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

open access: yesFEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz   +6 more
wiley   +1 more source

BROADBAND METHOD FOR GROUP VELOCITY DISPERSION MEASUREMENTS IN THE MID-INFRARED

open access: yesПриборы и методы измерений, 2015
A setup for broadband measurements of dispersion parameter in optical fibers based on the Mach–Zehnder interferometer is developed. Tm-doped fiber pumped at 1.61 μm was used as a source of broadband emission, that allowed to achieve the measurement ...
D. S. Klimentov   +3 more
doaj  

Experimentally Validated Dispersion Tailoring in a Silicon Strip Waveguide With Alumina Thin-Film Coating

open access: yesIEEE Photonics Journal, 2018
We propose a silicon strip waveguide structure with alumina thin-film coating in-between the core and the cladding for group-velocity dispersion tailoring.
Kai Guo   +7 more
doaj   +1 more source

Intermodal group velocity dispersion of few-mode fiber

open access: yesIEICE Electronics Express, 2010
The intermodal dispersion of few-mode fiber limits the propagation distance of mode division multiplexing (MDM). We numerically investigate the propagation constant and group velocity of few-mode fibers. The refractive index profile of few-mode fibers should be designed to achieve long and dense MDM transmissions with digital coherent receivers.
Hirokazu Kubota   +4 more
openaire   +1 more source

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