Results 51 to 60 of about 10,332,665 (292)
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Turbulent dispersion in cloud-topped boundary layers [PDF]
, 2009 Compared to dry boundary layers, dispersion in cloud-topped boundary layers has received less attention. In this LES based numerical study we investigate the dispersion of a passive tracer in the form of Lagrangian particles for four kinds of atmospheric
Vilà-Guerau de Arellano, J. (author) +11 more
core +3 more sources
Molecular Oncology, EarlyView.Taxanes are widely used chemotherapeutics whose effects on cellular mechanics remain poorly understood. We show that paclitaxel induces rapid cellular contraction by promoting GEF‐H1 dissociation from microtubules and non‐muscle myosin II activation through RhoA/ROCK.
Gloria Asensio‐Juárez +5 more
wiley +1 more source
Molecular Oncology, EarlyView.The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim +17 more
wiley +1 more source
, 2009 We report on the fabrication of a solid one-dimensional microstructured fiber with high nonlinearity and low dispersion at 1.55µm. A four-wave-mixing based tunable wavelength-conversion scheme was experimentally demonstrated in just 1.5m of this ...
Camerlingo, A. +7 more
core +1 more source
FEBS Open Bio, EarlyView.RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz +6 more
wiley +1 more source
Understanding Dispersion of Revolver-Type Anti-Resonant Hollow Core Fibers
Fibers, 2018 Here, we analyze the dispersion behavior of revolver-type anti-resonant hollow core fibers, revealing that the chromatic dispersion of this type of fiber geometry is dominated by the resonances of the glass annuluses, whereas the actual arrangement of ...
Matthias Zeisberger +2 more
doaj +1 more source
APL Photonics, 2023 We report measurements of Kerr nonlinearity and group velocity dispersion in In0.53Ga0.47As/InP and GaAs0.51Sb0.49/InP ridge waveguides in the mid-infrared using four-wave mixing at λ ≈ 5 µm.
Kevin Zhang +2 more
doaj +1 more source
地球与行星物理论评, 2023 Surface wave tomography using dispersion data to obtain isotropic and anisotropic shear wave velocity structures is a very efficient approach to study regional and global tectonics and deformation and to probe high-resolution crustal, upper mantle and ...
Huajian Yao +4 more
doaj +1 more source
Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies
FEBS Open Bio, EarlyView.We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli +8 more
wiley +1 more source