Results 41 to 50 of about 35,394 (266)

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Understanding Dispersion of Revolver-Type Anti-Resonant Hollow Core Fibers

open access: yesFibers, 2018
Here, we analyze the dispersion behavior of revolver-type anti-resonant hollow core fibers, revealing that the chromatic dispersion of this type of fiber geometry is dominated by the resonances of the glass annuluses, whereas the actual arrangement of ...
Matthias Zeisberger   +2 more
doaj   +1 more source

AscF in the mycobacterial CIII–CIV supercomplex lacks metal and nucleotide binding but links malate oxidation to respiration

open access: yesFEBS Letters, EarlyView.
The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile   +8 more
wiley   +1 more source

Confirmation of an Anomalously Low Dark Matter Content for the Galaxy NGC 1052-DF4 from Deep, High-resolution Continuum Spectroscopy

open access: yesThe Astrophysical Journal, 2023
NGC 1052-DF4 was found to be the second “galaxy lacking dark matter” in the NGC 1052 group, based on its velocity dispersion of ${\sigma }_{\mathrm{gc}}={4.2}_{-2.2}^{+4.4}$ km s ^−1 as measured from the radial velocities of seven of its globular ...
Zili Shen   +2 more
doaj   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

open access: yesMolecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch   +13 more
wiley   +1 more source

Kerr nonlinearity and group velocity dispersion of InGaAs/InP and GaAsSb/InP waveguides in the mid-infrared

open access: yesAPL Photonics, 2023
We report measurements of Kerr nonlinearity and group velocity dispersion in In0.53Ga0.47As/InP and GaAs0.51Sb0.49/InP ridge waveguides in the mid-infrared using four-wave mixing at λ ≈ 5 µm.
Kevin Zhang   +2 more
doaj   +1 more source

Direct surface wave tomography for three dimensional structure based on surface wave traveltimes: Methodology review and applications

open access: yes地球与行星物理论评, 2023
Surface wave tomography using dispersion data to obtain isotropic and anisotropic shear wave velocity structures is a very efficient approach to study regional and global tectonics and deformation and to probe high-resolution crustal, upper mantle and ...
Huajian Yao   +4 more
doaj   +1 more source

Galaxy groups: abundance by luminosity and by velocity dispersion [PDF]

open access: yesMonthly Notices of the Royal Astronomical Society, 1993
We present a reanalysis of groups in the Center for Astrophysics redshift survey, focusing on properties that can be readily compared with predictions of gravitational clustering theories. The grouping algorithm we employ is optimized using artificial catalogues constructed from N-body simulations that have similar low-order correlations to those of ...
B. Moore, C. S. Frenk, S. D. M. White
openaire   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

BROADBAND METHOD FOR GROUP VELOCITY DISPERSION MEASUREMENTS IN THE MID-INFRARED

open access: yesПриборы и методы измерений, 2015
A setup for broadband measurements of dispersion parameter in optical fibers based on the Mach–Zehnder interferometer is developed. Tm-doped fiber pumped at 1.61 μm was used as a source of broadband emission, that allowed to achieve the measurement ...
D. S. Klimentov   +3 more
doaj  

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