Results 61 to 70 of about 10,363,176 (246)

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +1 more source

A solid one-dimensional microstructured optical fiber with high nonlinearity and low dispersion at 1.55 microns

, 2009
We report on the fabrication of a solid one-dimensional microstructured fiber with high nonlinearity and low dispersion at 1.55µm. A four-wave-mixing based tunable wavelength-conversion scheme was experimentally demonstrated in just 1.5m of this ...
Camerlingo, A., Horak, P., Petropoulos, P., Parmigiani, F., Richardson, D.J., Poletti, F., Loh, W.H., Feng, X.   +7 more
core   +1 more source

Understanding Dispersion of Revolver-Type Anti-Resonant Hollow Core Fibers

Fibers, 2018
Here, we analyze the dispersion behavior of revolver-type anti-resonant hollow core fibers, revealing that the chromatic dispersion of this type of fiber geometry is dominated by the resonances of the glass annuluses, whereas the actual arrangement of ...
Matthias Zeisberger, Alexander Hartung, Markus A. Schmidt   +2 more
doaj   +1 more source

Kerr nonlinearity and group velocity dispersion of InGaAs/InP and GaAsSb/InP waveguides in the mid-infrared

APL Photonics, 2023
We report measurements of Kerr nonlinearity and group velocity dispersion in In0.53Ga0.47As/InP and GaAs0.51Sb0.49/InP ridge waveguides in the mid-infrared using four-wave mixing at λ ≈ 5 µm.
Kevin Zhang, Gerhard Böhm, Mikhail A. Belkin   +2 more
doaj   +1 more source

Automated FRAP microscopy for high‐throughput analysis of protein dynamics in chromatin organization and transcription

FEBS Open Bio, EarlyView.
RoboMic is an automated confocal microscopy pipeline for high‐throughput functional imaging in living cells. Demonstrated with fluorescence recovery after photobleaching (FRAP), it integrates AI‐driven nuclear segmentation, ROI selection, bleaching, and analysis.
Selçuk Yavuz, Bart Geverts, Johan A. Slotman, Andrea Sacchetti, Stefan Prekovic, Martin E. van Royen, Adriaan B. Houtsmuller   +6 more
wiley   +1 more source

BROADBAND METHOD FOR GROUP VELOCITY DISPERSION MEASUREMENTS IN THE MID-INFRARED

Приборы и методы измерений, 2015
A setup for broadband measurements of dispersion parameter in optical fibers based on the Mach–Zehnder interferometer is developed. Tm-doped fiber pumped at 1.61 μm was used as a source of broadband emission, that allowed to achieve the measurement ...
D. S. Klimentov, N. A. Tolstik, V. V. Dvoyrin, I. T. Sorokina   +3 more
doaj  

Experimentally Validated Dispersion Tailoring in a Silicon Strip Waveguide With Alumina Thin-Film Coating

IEEE Photonics Journal, 2018
We propose a silicon strip waveguide structure with alumina thin-film coating in-between the core and the cladding for group-velocity dispersion tailoring.
Kai Guo, Jesper. B. Christensen, Xiaodong Shi, Erik. N. Christensen, Li Lin, Yunhong Ding, Haiyan Ou, Karsten Rottwitt   +7 more
doaj   +1 more source

Single‐molecule DNA flow‐stretch assays for high‐throughput DNA–protein interaction studies

FEBS Open Bio, EarlyView.
We describe an optimised single‐molecule DNA flow‐stretch assay that visualises DNA–protein interactions in real time. Linear DNA fragments are tethered to a surface and stretched by buffer flow for fluorescence imaging. Using λ and φX174 DNA, this protocol enhances reproducibility and accessibility, providing a versatile approach for studying diverse ...
Ayush Kumar Ganguli, Mohammad Nour Alsamsam, Ugnė Bagdonaitė, Van Truc Vu, Chun‐Jen Huang, Polina Kuzhir, Mindaugas Zaremba, Aurimas Kopūstas, Marijonas Tutkus   +8 more
wiley   +1 more source

Confirmation of an Anomalously Low Dark Matter Content for the Galaxy NGC 1052-DF4 from Deep, High-resolution Continuum Spectroscopy

The Astrophysical Journal, 2023
NGC 1052-DF4 was found to be the second “galaxy lacking dark matter” in the NGC 1052 group, based on its velocity dispersion of ${\sigma }_{\mathrm{gc}}={4.2}_{-2.2}^{+4.4}$ km s ^−1 as measured from the radial velocities of seven of its globular ...
Zili Shen, Pieter van Dokkum, Shany Danieli   +2 more
doaj   +1 more source

Importin 7 mediates the nuclear import of HIV‐1 integrase via a specific interacting interface

FEBS Open Bio, EarlyView.
HIV‐1 integrase enables viral DNA integration into the host genome. By binding to the core domain of the host protein Importin 7 via its C‐terminal domain, the integrase is transported across the nuclear membrane into the nucleus, where integration of the viral genome into host DNA takes place. This translocation is a critical step for subsequent viral
Juana Bana, Avigail Yariv, Tal Oppenheim, Hadar Amartely, Dana Reichmann, Oded Livnah   +5 more
wiley   +1 more source