Results 41 to 50 of about 53,070 (250)

Italian compliance programmes in groups of companies

open access: yes, 2013
Legislative Decree 231/01 introduced corporate criminal liability into the Italian legal system: companies are exempted from the liability if they set up and implement a suitable compliance programme (called ‘Model 231’).Recent statements in the sphere ...
ROSSIGNOLI, Francesca
core   +1 more source

Patient therapy outcome modeling in cancer organoids is improved by cancer‐associated fibroblasts and organoid assembly convolution

open access: yesMolecular Oncology, EarlyView.
Patient‐derived organoids (PDOs) from pancreatic, colorectal, and gastric cancers were used to evaluate standard and experimental therapies. Incorporating cancer‐associated fibroblasts (CAFs) into organoid cultures improved patient therapy outcome prediction.
Marcin Grochowski   +12 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

open access: yesFEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel   +4 more
wiley   +1 more source

Ownership Characteristics and Access to Finance: Evidence from a Survey of Large Privatised Companies in Hungary and Poland [PDF]

open access: yes, 2003
We examine financial constraints and forms of finance used for investment, by analysing survey data on 157 large privatised companies in Hungary and Poland for the period 1998 - 2000.
Isachenkova, N   +3 more
core   +1 more source

Integrated investment- innovation processes groups of companies: essence and sequence [PDF]

open access: yesMarketing i Menedžment Innovacij, 2012
The authors elucidate the nature, content and implementation stages of an integrated investment -innovation process.
E.N. Chupyr
doaj  

Information Technology Governance Disclosure in Annual Report of Indonesia Financial Institutions

open access: yesCommIT Journal, 2020
The research aims to analyze the level of information technology (IT) governance disclosure in the annual report of financial companies and influencing factors in the exposure of IT governance. It distinguishes financial companies into two groups, namely
Weli Weli
doaj   +1 more source

The Characteristics of the Open Innovation Model Application in Slovenian Firms [PDF]

open access: yesDynamic Relationships Management Journal (DRMJ), 2015
This paper analyses the characteristics of the model of open innovation in Slovenia. On the basis of activities that are defined by the model of open innovation (Chesbrough, 2003) 222 companies are divided into three groups : companies that do not apply ...
Daša Farčnik, Tjaša Redek
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

open access: yesFEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia   +3 more
wiley   +1 more source

Blood‐based proteomic profiling reveals context‐dependent changes in BCL2‐associated signaling during taxane therapy in breast cancer patients

open access: yesFEBS Open Bio, EarlyView.
Chemotherapy side effects significantly impact cancer survivors' quality of life. Using protein levels in blood samples from breast cancer patients before and after 12 weeks of taxane treatment, we detected treatment‐dependent changes in calcium signaling and aging pathways associated with cancer recurrence.
Saira Munshani   +6 more
wiley   +1 more source

Social innovation: the process development of knowledge-intensive companies [PDF]

open access: yes, 2012
The new service development of knowledge-intensive companies in emerging economies is changing from processes with only economic goals to processes that combine economic and social needs.
Sandro Battisti, Battisti, Sandro
core   +1 more source

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