Results 61 to 70 of about 1,784,322 (295)

The broiler meat system in Nairobi, Kenya: using a value chain framework to understand animal and product flows, governance and sanitary risks [PDF]

, 2017
Livestock food systems play key subsistence and income generation roles in low to middle income countries and are important networks for zoonotic disease transmission.
AfDB, APHRC, Barbara Häsler, Cornelsen, Eric M. Fèvre, Fafchamps, GoK, GoK, Greger, Havelaar, Higham, IIED, James Akoko, Jonathan Rushton, Joshua Onono, Kaplinsky, Kariuki, Kimenyi, Landers, Manning, Marshall, Martellozzo, Maud Carron, Maurice Karani, McCarron, Meakins, Narrod, Neven, Okello, Omiti, Pablo Alarcon, Patrick Muinde, Robinson, Rushton, Rushton, Shiferaw, Thuo, Van Boeckel, WHO, Zhao   +39 more
core   +2 more sources

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Trading Data for Discounts: An Exploration of Unstructured Data Through Machine Learning in Wearable Technology [PDF]

, 2017
The development of computing sensor devices with the capability of tracking an individual’s activity changed the way we live and move. The data collected and generated from wearable technology provides implications to the user for leading a healthy, more
Zukowski, Kaleigh Alexis
core   +1 more source

Microglial dynamics and ferroptosis induction in human iPSC‐derived neuron–astrocyte–microglia tri‐cultures

FEBS Open Bio, EarlyView.
A tri‐culture of iPSC‐derived neurons, astrocytes, and microglia treated with ferroptosis inducers as an Induced ferroptosis model was characterized by scRNA‐seq, cell survival, and cytokine release assays. This analysis revealed diverse microglial transcriptomic changes, indicating that the system captures key aspects of the complex cellular ...
Hongmei Lisa Li, Hiroko Ohmiya, Sou Sakamoto, Masato Yugami, Akiko Oki, Makoto Furusawa, Yan Ling   +6 more
wiley   +1 more source

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Learning From Our Mistakes: Corporate Front Groups and the Limits of Revelation in Climate Politics

Social Media + Society, 2023
Fossil fuel companies have made major investments in mobilizing citizen support in recent decades, funding advocacy groups to stoke climate denial, doubt, and delay.
Tim Wood
doaj   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Article Oh Captain(s)! My Captain(s)

European Insolvency and Restructuring Journal
In this article, the author examines to what extent the European Insolvency Regulation (recast) authorizes Member States' courts to cooperate cross-border through appointing the same insolvency practitioner in insolvency proceedings relating to group ...
Sid Pepels
doaj   +1 more source

Suppression of lung adenocarcinoma migration through organelle alkalization by human lactoferrin – albumin fusion

FEBS Open Bio, EarlyView.
This paper reveals how human lactoferrin–albumin fusion (hLF‐HSA) potently suppresses lung adenocarcinoma cell migration. hLF‐HSA upregulates NHE7, leading to Golgi alkalization, disruption of the Golgi secretome, downregulation of MMP1, and reversal of EMT. These findings suggest a novel Golgi‐targeting strategy to suppress cancer cell migration.
Hana Nopia, Masahiro Kimura, Daisuke Kurimoto, Atsushi Sato   +3 more
wiley   +1 more source

ANALYSIS OF THE EFFICIENCY OF RED CERAMIC COMPANIES IN THE REGION OF CARAJÁS-PA

Revista Produção e Desenvolvimento, 2018
The purpose of this paper is to analyze the efficiency of companies in the ceramic sector located in the region of Carajás / PA, based on Data Envelopment Analysis (DEA), using as information base data collected from 21 local companies.
Fayla Fabiana Soares dos Santos, Sérgio Castro Gomes, Keila Regina Mota Negrão, Américo Johny Melo   +3 more
doaj   +1 more source