Results 101 to 110 of about 3,661,637 (292)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Hasse-Minkowski theorem for quadratic forms on Mordell-Weil type groups

, 2017
In this paper we investigate an analogue of Hasse-Minkowski theorem for quadratic forms on Mordell-Weil type groups over number fields like $S$-units, abelian varieties with trivial ring of endomorphisms and odd algebraic $K$-theory ...
Barańczuk, Stefan
core  

Structural biology of ferritin nanocages

FEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

FORMULATICITY OF THE INCOMPLETE SYNTACTIC FORM OF AN IMPERATIVE STATEMENT IN DISCOURSE

Sovremennye Issledovaniâ Socialʹnyh Problem
Background. Language units functioning in specific discourse conditions undergo desemantization and gramaticalization, which results in new discourse units forming. These units perform relevant discourse functions and carry communicative meanings.
Iuliia А. Nenasheva
doaj   +1 more source

Nicotinamide N‐methyltransferase promotes drug resistance in lung cancer, as revealed by nascent proteomic profiling

Molecular Oncology, EarlyView.
AZD9291 has shown promise in targeted cancer therapy but is limited by resistance. In this study, we employed metabolic labeling and LC–MS/MS to profile time‐resolved nascent protein perturbations, allowing dynamic tracking of drug‐responsive proteins. We demonstrated that increased NNMT expression is associated with drug resistance, highlighting NNMT ...
Zhanwu Hou, Zhen Wang, Fei Yang, Xiao Han, Lei Li, Huadong Liu   +5 more
wiley   +1 more source

The Effect of Education of Medication by Small Groups Discussion on Nursing Adherence in Intensive Care Units of Medication Standards

مراقبت پرستاری و مامایی ابن سینا, 2019
Introduction: Adherence of standards requires the continuous of education for nurses. Effective educational methods for increasing knowledge and enhancing skills is group discussion.
Gholam Hossein Falahinia, Arezoo Maleki, Zahra Khalili, Alireza Soltanian   +3 more
doaj  

Unit groups of infinite abelian extensions [PDF]

Proceedings of the American Mathematical Society, 1970
Let F be a finite extension field of the rational numbers, 0, and let K be an infinite abelian extension of F. Let 5 be a finite set of prime divisors of Q including the Archimedean one. An 5-unit of K is a field element which is a local unit at all prime divisors of F which do not restrict on Q to a member of 5.
openaire   +2 more sources

Characterizing the salivary RNA landscape to identify potential diagnostic, prognostic, and follow‐up biomarkers for breast cancer

Molecular Oncology, EarlyView.
This study explores salivary RNA for breast cancer (BC) diagnosis, prognosis, and follow‐up. High‐throughput RNA sequencing identified distinct salivary RNA signatures, including novel transcripts, that differentiate BC from healthy controls, characterize histological and molecular subtypes, and indicate lymph node involvement.
Nicholas Rajan, Irina Primac, Emre Etlioglu, Laurens Debruyne, Ann Janssen, Magy Sallam, Kevin Tabury, Roel Quintens, Wiebren Tjalma, Mohammed Abderrafi Benotmane   +9 more
wiley   +1 more source

DERIVATIONAL MECHANISMS FOR MODELING OCCASIONAL VOCABULARY IN THE RUSSIANLANGUAGE MEDIA SPACE (ON THE EXAMPLE OF THE PREFIX DE-)

Известия Южного федерального университета: Филологические науки
This study is devoted to the study of the implementation features of derivational mechanisms for modeling occasional vocabulary in the Russian-language media space.
Anatoliy P. Chudinov, Natalya А. Segal, Anna N. Mishchenko   +2 more
doaj   +1 more source