Results 81 to 90 of about 1,277,019 (268)
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Wittig reaction of cyclobisbiphenylenecarbonyl
Beilstein Journal of Organic ChemistryCyclobisbiphenylenecarbonyl (CBBC) represents a readily available chiral figure-eight macrocycle containing two carbonyl groups. However, the transformation of the carbonyl groups has been unexplored. Herein, we conducted the Wittig reaction of CBBC with
Taito Moribe +4 more
doaj +1 more source
Group algebras of Kleinian type and groups of units
Journal of Algebra, 2007 The algebras of Kleinian type are finite dimensional semisimple rational algebras $A$ such that the group of units of an order in $A$ is commensurable with a direct product of Kleinian groups. We classify the Schur algebras of Kleinian type and the group algebras of Kleinian type.
Del Rio Mateos, Angel +1 more
openaire +4 more sources
Ligand‐dependent transcriptional heterogeneity in cell cycle gene expression delays G1/S entry
FEBS Letters, EarlyView.EGF and HRG induce distinct G1/S progression programs in ErbB2‐amplified BT474 breast cancer cells. Despite activating the potent ErbB2–ErbB3 heterodimer, HRG does not accelerate cell‐cycle entry. Instead, EGF promotes earlier restriction‐point passage via ERK–FOS signaling, whereas HRG activates the AKT–MYC axis, driving transcriptional heterogeneity ...
Ririn Rahmala Febri +5 more
wiley +1 more source
Известия Южного федерального университета: Филологические наукиThis study is devoted to the study of the implementation features of derivational mechanisms for modeling occasional vocabulary in the Russian-language media space.
Anatoliy P. Chudinov +2 more
doaj +1 more source
The Normalizer of a Group in the Unit Group of Its Group Ring
Journal of Algebra, 1999 The author studies the normalizer \(N\) of a group \(G\) in its group ring \(RG\). More precisely, let \(G\) be a not necessarily finite group and let \(R\) be any commutative ring. Then, conjugation by \(N\) gives automorphisms on \(G\) and the corresponding group of automorphisms is denoted by \(\Aut_R(G)\).
openaire +2 more sources
FEBS Letters, EarlyView.How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley +1 more source
RUDN Journal of Language Studies, Semiotics and Semantics, 2011 The subject of the research is the comparison of English and Russian phraseological units which include partonyms of the somatism HEAD. Somatic phraseological units are connected as synonyms, antonyms, homonyms and polysemantic words.
T G Orlova, E F Nikulina
doaj
The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation
FEBS Letters, EarlyView.Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge +6 more
wiley +1 more source