Results 31 to 40 of about 54,116 (311)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

PREDIKSI FINANSIAL DISTRESS DENGAN METODE ALTMAN Z-SCORE, ZMIJEWSKI, DAN GROVER PADA PERUSAHAAN SAWIT TERINDEKS SAHAM SYARIAH PERIODE 2020-2022

Lisan Al-Hal: Jurnal Pengembangan Pemikiran dan Kebudayaan
The primary aim of this research is to analyze the financial challenges encountered by sharia-compliant palm oil companies, along with assessing the variances in financial distress prognostications among the Altman Z-Score, Zmijewski, and Grover ...
Abd Hadi, Dahruji Dahruji, Joni Joni
doaj   +1 more source

Endoscopic findings in patients with Shwachman-Diamond syndrome: A report from the North American Shwachman-Diamond syndrome registry. [PDF]

JPGN Rep
Abstract Objectives Shwachman–Diamond syndrome (SDS) is an inherited bone marrow failure disorder, and its endoscopic phenotype is poorly defined. We sought to characterize endoscopic findings in patients with genetically confirmed SDS. Methods Retrospective registry study of 45 patients with biallelic Shwachman–Bodian–Diamond syndrome mutations and ...
Korn E, Koo J, Schwarz D, Haney M, Putra J, Kim J, Cheng L, Steltz S, Schwarz L, Loveless S, Cooper R, Dusa C, Myers KC, Shimamura A, Wehrman A, Grover AS.   +15 more
europepmc   +2 more sources

A novel quinazolinone insulin receptor inhibitor and its synergy with an EGFR inhibitor in glucose‐driven glioblastoma

Molecular Oncology, EarlyView.
The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka, Wioleta Cieślik, Wojciech Płaziński, Katarzyna Stępnik, Anna Boguszewska‐Czubara, Elżbieta Kot, Robert Musioł, Mateusz Jasica, Anna Mrozek‐Wilczkiewicz, Katarzyna Malarz   +9 more
wiley   +1 more source

Noise analysis of Grover and phase estimation algorithms implemented as quantum singular value transformations for a small number of noisy qubits

Scientific Reports, 2023
The quantum singular value transformation (QSVT) algorithm is a general framework to implement most of the known algorithms and provides a way forward for designing new algorithms.
Muhammad Abdullah Ijaz, Muhammad Faryad
doaj   +1 more source

Grover–Sagnac interferometer

Journal of the Optical Society of America A
We demonstrate a nontraditional design of the Sagnac interferometer by replacing the commonly used beam splitter with a linear-optical Grover multiport. This substitution creates a pole at the origin of the device parameter space, with an associated resonance in the output intensity.
Christopher R. Schwarze, Anthony D. Manni, David S. Simon, Abdoulaye Ndao, Alexander V. Sergienko   +4 more
openaire   +3 more sources

Aquaporin‐3 and aquaporin‐5 impact the development of pancreatic ductal adenocarcinoma spheroids

FEBS Open Bio, EarlyView.
Schematic representation of the role of aquaporin‐3 (AQP3) and aquaporin‐5 (AQP5) in pancreatic ductal adenocarcinoma (PDAC). Both proteins are upregulated in PDAC and are associated with tumor progression and metastatic potential. Silencing AQP3 or AQP5 in PDAC spheroids results in decreased diameter, area, and overall growth, underscoring their key ...
Catarina Pimpão, Diogo M. Engrácia, Graça Soveral, Filipa Mendes   +3 more
wiley   +1 more source

Financial Distress Using the Zmijewski, Grover, and Springate Models at Retail Business in Indonesia

Jurnal Cendekia Keuangan
Introduction/Main Objectives: This study aims to analyze PT Matahari Putra Prima's financial health during 2018-2022 using the Zmijewski, Grover, and Springate models to predict potential financial distress.
Erni Muti’atul Fitriyah, Karari Budi Prasasti   +1 more
doaj   +1 more source

Salmonella enterica serovar typhi limits the potency of typhoid toxin and ADP‐ribosylating toxin AB to establish a persistent infection

FEBS Open Bio, EarlyView.
The two catalytic subunits of typhoid toxin dissociate from the holotoxin in the ER of an intoxicated cell, but only CdtB exits the ER to generate immunosuppressive effects. PltA is retained in the ER and sequestered from its cytosolic target, thus allowing the anti‐inflammatory effects of CdtB to promote intestinal colonization.
Maria C. Zabala‐Rodriguez, Juliette K. Tinker, Teresa Frisan, Taj Azarian, Ken Teter   +4 more
wiley   +1 more source

Zwitterionic Polymer Coating Enabled Chronic Dopamine Sensing and Electrophysiology Recording in Free‐Moving Mice

Advanced Healthcare Materials, EarlyView.
Application of a zwitterionic poly(sulfobetaine methacrylate) (PSB) coating to microelectrode arrays and Ag/AgCl reference electrodes effectively inhibits biofouling and structural degradation. This strategy successfully enables simultaneous, long‐term electrophysiological recording and dopamine sensing in freely behaving mice, facilitating ...
Bingchen Wu, Cort Thompson, Thomas Deakin, Yan Xu, Colleen A. McClung, Xinyan Tracy Cui   +5 more
wiley   +1 more source