Results 121 to 130 of about 7,515,536 (268)
Cooling Degree Days and Hours for Latvia
Calculation of cooling degree days is currently one of the most commonly used methods in heating, ventilation and air conditioning (HVAC) industry to describe the effect of outside air temperature on building cooling energy consumption.
Stankeviča, Gaļina
core
Pharmacological chromatin remodeling enhances response to estrogen therapy in ER+ breast cancer
Molecular Oncology, EarlyView.Estrogen therapy elicits clinical benefit in ~ 30% of patients with endocrine‐resistant estrogen receptor (ER)‐positive breast cancer. Based on findings that ER transcriptional activation underlies response to estrogen therapy, we tested the effects of epigenetic dysregulation via pharmacological inhibition of histone deacetylases (HDACi).
Anneka L. Johnson Thomas +16 more
wiley +1 more source
Korean Journal of Horticultural Science and Technology, 2021 H. Sim +7 more
semanticscholar +1 more source
Molecular Oncology, EarlyView.We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee +3 more
wiley +1 more source
Prediction of Crops Cycle with Seasonal Forecasts to Support Decision-Making
AgronomyClimate variability, intensified by climate change, poses significant challenges to agriculture, affecting crop development and productivity. Integrating seasonal weather forecasts (SWF) into crop growth modelling tools is therefore essential for ...
Daniel Garcia +6 more
doaj +1 more source
Molecular Oncology, EarlyView.Partial inhibition of focal adhesion kinase (FAK) can paradoxically promote tumor growth, rather than simply producing a weaker antitumor effect than that observed with strong FAK suppression. In breast cancer and melanoma models, targeting p110δ PI3K, particularly in macrophages, counteracted these tumor‐promoting effects, highlighting the importance ...
Lydia Xenou +4 more
wiley +1 more source
LOSS MODEL OF CLIMATE INSURANCE BASED ON EFFECT OF GROWING DEGREE DAYS INDEX [PDF]
Climate change is a threat to agriculture, especially food crops such as rice. Climate index insurance is an alternative to cover the risk of agricultural losses due to crop failure due to climate change factors.
Sapto Wahyu Indratno +7 more
core +1 more source
Molecular Oncology, EarlyView.Loss of NAPRT promotes lung tumor initiation and growth through a noncanonical mechanism, independent of its role in NAD+ biosynthesis. Mechanistically, NAPRT depletion activates the mTORC2‐driven AKT/β‐catenin signaling axis to enhance clonogenic and invasive phenotypes. Furthermore, lung‐specific Naprt deletion significantly increases tumor burden in
Myung Joon Oh +11 more
wiley +1 more source