Results 251 to 260 of about 8,870,290 (313)

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Phase Separation-Regulated Fungal Growth, Sexual Development, Adaptation and Synthetic Biology Applications. [PDF]

J Fungi (Basel)
Tong X, Zhang D, Zhu Z.
europepmc   +1 more source

FGFR Like1 drives esophageal cancer progression via EMT, PI3K/Akt, and notch signalling: insights from clinical data and next‐generation sequencing analysis

FEBS Open Bio, EarlyView.
Clinical analysis reveals significant dysregulation of FGFRL1 in esophageal cancer (EC) patients. RNAi‐coupled next‐generation sequencing (NGS) and in vitro study reveal FGFRL1‐mediated EC progression via EMT, PI3K/Akt, and Notch pathways. Functional assays confirm its role in tumor growth, migration, and invasion.
Aprajita Srivastava, Anoop Saraya, Deepak Gunjan, Rinu Sharma   +3 more
wiley   +1 more source

A histone deacetylase complex regulates anthocyanin biosynthesis during normal plant growth and development and in response to jasmonate. [PDF]

Plant Commun
Huang F, Zhang Z, Gu J, Shen C, Wang D, Gao B, He Y.   +6 more
europepmc   +1 more source

Evaluation of in vitro toxicity of common phytochemicals included in weight loss supplements using 1H NMR spectroscopy

FEBS Open Bio, EarlyView.
We investigated the toxicity of 12 active compounds commonly found in herbal weight loss supplements (WLS) using human liver and colon cell models. Epigallocatechin‐3‐gallate was the only compound showing significant toxicity. Metabolic profiling revealed protein degradation, disrupted energy and lipid metabolism suggesting that the inclusion of EGCG ...
Emily C. Davies, Garth L. Maker, Ian F. Musgrave, Samantha Lodge   +3 more
wiley   +1 more source

KLK7 overexpression promotes an aggressive phenotype and facilitates peritoneal dissemination in colorectal cancer cells

FEBS Open Bio, EarlyView.
KLK7, a tissue kallikrein‐related peptidase, is elevated in advanced colorectal cancer and associated with shorter survival. High KLK7 levels in ascites correlate with peritoneal metastasis. In mice, KLK7 overexpression increases metastasis. In vitro, KLK7 enhances cancer cell proliferation, migration, adhesion, and spheroid formation, driving ...
Yosr Z. Haffani, Tobias Dreyer, Meriem Naim, Rea Lo Dico, Natalia A. Ignatenko, Viktor Magdolen, Dalila Darmoul   +6 more
wiley   +1 more source

MYB gene from Endocarpon pusillum regulates growth and development and enhances drought tolerance in creeping bentgrass (Agrostis stolonifera L.). [PDF]

BMC Plant Biol
Ai Y, Liu J, Chen Y, Qian X, Chen J, Li J, Xu L, Sun X, Ran F, Han L, Chao Y.   +10 more
europepmc   +1 more source

Dietary Proline Supplementation Promotes Growth and Development in Weaned Foals by Modulating Gut Microbial Amino Acid Metabolism. [PDF]

Microorganisms
Meng C, Wang J, Zeng Y, Yao X, Meng J.
europepmc   +1 more source

<i>ZmHPAT2</i> Regulates Maize Growth and Development and Mycorrhizal Symbiosis. [PDF]

Plants (Basel)
Xie K, Wang G, Ni Y, Shi M, Sun L, Cheng B, Li X.   +6 more
europepmc   +1 more source

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Growth and development

Journal of Pediatric Health Care, 1987
A sthma is a reversible obstructive airway disease. It is the most common chronic health problem seen in children, occurring in approximately 3% of all children. As in the case of all chronic illnesses, asthma may cause or exacerbate stressors that affect both the child and the family. It is generally agreed that the cause of asthma is multifaceted and
openaire   +2 more sources