Results 81 to 90 of about 7,518,884 (305)

Stimulator of interferon genes agonist augmented antitumor immunity of osimertinib in Egfr‐mutated lung cancer

open access: yesMolecular Oncology, EarlyView.
Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura   +19 more
wiley   +1 more source

grofit: Fitting Biological Growth Curves with R [PDF]

open access: yes
The grofit package was developed to fit many growth curves obtained under different conditions in order to derive a conclusive dose-response curve, for instance for a compound that potentially affects growth.
Jost Ludwig   +4 more
core  

Crescimento e produção de brócolis em sistema orgânico em função de doses de composto Growth and yield of broccoli on organic production system as a function of compost dosages

open access: yesCiência e Agrotecnologia, 2008
A utilização de composto orgânico na produção de olerícolas resulta em efeitos diversos e complexos. Embora seja crescente a pesquisa voltada para a produção orgânica de olerícolas, os efeitos do composto orgânico sobre o crescimento e a produção dessas ...
Ellen Rúbia Diniz   +5 more
doaj   +1 more source

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

open access: yesMolecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur   +11 more
wiley   +1 more source

Economic growth and atmospheric pollution in Spain: discussing the environmental Kuznets curve by hypothesis [PDF]

open access: yes
The environmental Kuznets curve (EKC) hypothesis posits an inverted U relationship between environmental pressure and per capita income. Recent research has examined this hypothesis for different pollutants in different countries.
Vittorio Galletto   +3 more
core  

Influence of soft cheese technology on the growth and enterotoxin production of Staphylococcus aureus

open access: yesCzech Journal of Food Sciences, 2009
The aim of this study was to monitor S. aureus growth and toxin production in soft cheese during the technological processing. In model experiments, raw milk was inoculated separately with five S. aureus strains isolated from milk and milk products.
Lenka Necidová   +6 more
doaj   +1 more source

An Interpretation of Cell Growth Curves [PDF]

open access: yesPlant Physiology, 1971
It is shown that typical cell elongation curves with time, as reported in the literature, are the consequence of a very simple trend of relative elemental elongation rate with time.
openaire   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

open access: yesMolecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington   +10 more
wiley   +1 more source

An Empirical Study of the Relationships between CO2 Emissions, Economic Growth and Openness [PDF]

open access: yes
This paper investigates the existence of the environmental Kuznets curve (EKC) for carbon dioxide (CO2) emissions and its causal relationships with economic growth and openness by using time series data (1971-2006) from China (an emerging market), Korea (
Heshmati, Almas   +2 more
core  

A new framework for yield curve, output and inflation relationships [PDF]

open access: yes, 2005
This article develops a theoretically-consistent and easy-to-apply framework for interpreting, investigating, and monitoring the relationships between the yield curve, output, and inflation.
Krippner, Leo
core  

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