Results 61 to 70 of about 661,033 (263)

Valosin‐containing protein counteracts ATP‐driven dissolution of FUS condensates through its ATPase activity in vitro

FEBS Letters, EarlyView.
Biomolecular condensates formed by fused in sarcoma (FUS) are dissolved by high ATP concentrations yet persist in cells. Using a reconstituted system, we demonstrate that valosin‐containing protein (VCP), an AAA+ ATPase, counteracts ATP‐driven dissolution of FUS condensates through its D2 ATPase activity.
Hitomi Kimura, Shin‐ichi Tate, Kyota Yasuda   +2 more
wiley   +1 more source

Aggressive prostate cancer is associated with pericyte dysfunction

Molecular Oncology, EarlyView.
Tumor‐produced TGF‐β drives pericyte dysfunction in prostate cancer. This dysfunction is characterized by downregulation of some canonical pericyte markers (i.e., DES, CSPG4, and ACTA2) while maintaining the expression of others (i.e., PDGFRB, NOTCH3, and RGS5).
Anabel Martinez‐Romero, Ane Martinez‐Larrinaga, Joaquim Grego‐Bessa, Saioa Garcia‐Longarte, Hielke van Splunder, Ianire Astobiza, Amaia Ercilla, Laura Bozal‐Basterra, Isabel Mendizabal, Pilar Villacampa, Arkaitz Carracedo, Mariona Graupera   +11 more
wiley   +1 more source

Proposal for a new non-linear model to describe growth curves

Bioscience Journal
This study was developed with longitudinal data measurements of Norfolk rabbits from birth to 119 days of age to estimate the average growth curve, with the primary objective of proposing a non-linear model.
André Luiz Pinto dos Santos, Tiago Alessandro Espínola Ferreira, Cícero Carlos Ramos de Brito, Frank Gomes-Silva, Guilherme Rocha Moreira   +4 more
doaj   +1 more source

Plasma extrachromosomal circular DNA as a biomarker in EGFR‐targeted therapy of non‐small cell lung cancer

Molecular Oncology, EarlyView.
Detection of extrachromosomal circular DNA (eccDNA) in plasma samples from EGFR‐mutated non‐small cell lung cancer patients. Plasma was collected before and during treatment with the EGFR‐tyrosine kinase inhibitor osimertinib. Plasma eccDNA was detected in all cancer samples, and the presence of the EGFR gene on eccDNA serves as a potential biomarker ...
Simone Stensgaard, Sarmad Mehmood, Eva Boysen Fynboe Ebert, Peter Meldgaard, Anindya Dutta, Boe S. Sorensen   +5 more
wiley   +1 more source

Growth Curve Models and Clustering Techniques for Studying New Sugarcane Hybrids

AgriEngineering
Sugarcane (Saccharum spp.) is a crop of significant industrial and nutritional value, essential for producing various products. Due to its importance, genetic improvement programs involve a rigorous selection process.
Carlos David Carretillo Moctezuma, María Guzmán Martínez, Flaviano Godínez-Jaimes, José C. García-Preciado, Ramón Reyes Carreto, José Terrones Salgado, Edgar Pérez Arriaga   +6 more
doaj   +1 more source

A Bayesian analysis of the effect of selection for growth rate on growth curves in rabbits

Genetics Selection Evolution, 2003
Gompertz growth curves were fitted to the data of 137 rabbits from control (C) and selected (S) lines. The animals came from a synthetic rabbit line selected for an increased growth rate.
Piles Miriam, Blasco Agustín, Varona Luis   +2 more
doaj   +1 more source

Cytoplasmic p21 promotes stemness of colon cancer cells via activation of the NFκB pathway

Molecular Oncology, EarlyView.
Cytoplasmic p21 promotes colorectal cancer stem cell (CSC) features by destabilizing the NFκB–IκB complex, activating NFκB signaling, and upregulating BCL‐xL and COX2. In contrast to nuclear p21, cytoplasmic p21 enhances spheroid formation and stemness transcription factor CD133.
Arnatchai Maiuthed, Kerstin Huebner, Katharina Erlenbach‐Wuensch, Chuanpit Hampel, Daniela Thalheim, Adriana Vial‐Roehe, Bodee Nutho, Susanne Merkel, Arndt Hartmann, Pithi Chanvorachote, Regine Schneider‐Stock   +10 more
wiley   +1 more source

Seasonal stem growth analysis shows early stem growth of Miscanthus from high latitudes yields more biomass but stem traits negatively interact to limit seasonal growth

Frontiers in Plant Science
High yielding perennial grasses are utilised as biomass for the bioeconomy and to displace fossil fuels. Miscanthus is a perennial grass used as a source of biomass but most of the cultivated crop is limited to a naturally occurring hybrid M. × giganteus.
Paul R. H. Robson, Sarah Hawkins, Christopher L. Davey, John C. Clifton-Brown, Gancho Slavov   +4 more
doaj   +1 more source

Dual targeting of RET and SRC synergizes in RET fusion‐positive cancer cells

Molecular Oncology, EarlyView.
Despite the strong activity of selective RET tyrosine kinase inhibitors (TKIs), resistance of RET fusion‐positive (RET+) lung cancer and thyroid cancer frequently occurs and is mainly driven by RET‐independent bypass mechanisms. Son et al. show that SRC TKIs significantly inhibit PAK and AKT survival signaling and enhance the efficacy of RET TKIs in ...
Juhyeon Son, Lily L. Remsing Rix, Bin Fang, Eric A. Welsh, Nicole V. Bremer, Valentina Foglizzo, Paola Roa, Nickole Sigcha‐Coello, Yi Liao, Eric B. Haura, Alexander Drilon, John M. Koomen, Emiliano Cocco, Uwe Rix   +13 more
wiley   +1 more source

Avaliação antropométrica de crianças indígenas menores de 60 meses, a partir do uso comparativo das curvas de crescimento NCHS/1977 e OMS/2005 Anthropometric evaluation of indigenous Brazilian children under 60 months of age using NCHS/1977 and WHO/2005 growth curves

Jornal de Pediatria, 2009
OBJETIVOS: Descrever e analisar comparativamente os dados antropométricos de crianças indígenas Suruí, Xavánte e Wari' menores de 60 meses, a partir dos conjuntos de curvas de crescimento NCHS/1977 e WHO/2005.
Jesem D. Y. Orellana, Ricardo V. Santos, Carlos E. A. Coimbra Jr., Maurício S. Leite   +3 more
doaj   +1 more source