Results 61 to 70 of about 686,506 (262)
From mice to humans—divergent strategies for intestinal homeostasis and regeneration
FEBS Letters, EarlyView.Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa +2 more
wiley +1 more source
Phosphoinositides and inositol phosphates as molecular glues
FEBS Letters, EarlyView.Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry +9 more
wiley +1 more source
Growth curves and reference centiles [PDF]
Developmental Medicine & Child Neurology, 2019 This commentary is on the original article by Bartlett et al. on pages 469–476 of this issue.
openaire +2 more sources
Proposal for a new non-linear model to describe growth curves
Bioscience JournalThis study was developed with longitudinal data measurements of Norfolk rabbits from birth to 119 days of age to estimate the average growth curve, with the primary objective of proposing a non-linear model.
André Luiz Pinto dos Santos +4 more
doaj +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
Growth Curve Models and Clustering Techniques for Studying New Sugarcane Hybrids
AgriEngineeringSugarcane (Saccharum spp.) is a crop of significant industrial and nutritional value, essential for producing various products. Due to its importance, genetic improvement programs involve a rigorous selection process.
Carlos David Carretillo Moctezuma +6 more
doaj +1 more source
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
Frontiers in Plant ScienceHigh yielding perennial grasses are utilised as biomass for the bioeconomy and to displace fossil fuels. Miscanthus is a perennial grass used as a source of biomass but most of the cultivated crop is limited to a naturally occurring hybrid M. × giganteus.
Paul R. H. Robson +4 more
doaj +1 more source
A Bayesian analysis of the effect of selection for growth rate on growth curves in rabbits
Genetics Selection Evolution, 2003 Gompertz growth curves were fitted to the data of 137 rabbits from control (C) and selected (S) lines. The animals came from a synthetic rabbit line selected for an increased growth rate.
Piles Miriam +2 more
doaj +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source