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Growth Hormone and Growth Hormone Secretagogues in Adults [PDF]
, 1999 The association of growth hormone (GH) with the promotion of linear growth in childhood has focused attention away from its role in adults, but GH secretion continues throughout life, reaching a maximum in adolescence and then declining progressively with age.
George R. Merriam, David E. Cummings
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Growth Hormone-Releasing Hormone*
Endocrine Reviews, 1986The identification of GRH has been followed by an extraordinarily rapid rate of knowledge accumulation. Within a period of slightly more than 3 yr since the structure of the GRH was determined, nearly 500 papers have been published pertaining to the hormone. Extensive knowledge of its anatomy, chemistry, molecular biology, physiology, and pathology has
Lawrence A. Frohman, John-Olov Jansson
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Growth Hormone in Osteoporosis [PDF]
Calcified Tissue Research, 1975 In 1972, Harris et al. (1) reported a marked increase of cortical bone formation and calcium accretion in adult dogs treated with high doses of growth hormone. Since in osteoporosis, bone formation is insufficient to compensate for the bone loss, human growth hormone (HGH) appears to be a promising substance for the treatment of this bone condition ...
M. A. Dambacher +7 more
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Pediatrics, 1966
THE RECENT cascade of knowledge of the chemistry and physiology of the protein and polypeptide hormones of the pituitary gland has been a consequence of steady progress over the past 20 years in methods of isolation, purification, and assay of these hormones.
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THE RECENT cascade of knowledge of the chemistry and physiology of the protein and polypeptide hormones of the pituitary gland has been a consequence of steady progress over the past 20 years in methods of isolation, purification, and assay of these hormones.
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European Journal of Pediatrics, 1989
Seven children with growth hormone deficiency of hypothalamic origin responded to an i.v. bolus of growth hormone releasing hormone (GHRH) (1-29)-NH2 with a mean serum increase of 10.7 ng/ml growth hormone (GH) (range 2.5-29.3 ng/ml). Continuous s.c.
B Staudt, O Butenandt
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Seven children with growth hormone deficiency of hypothalamic origin responded to an i.v. bolus of growth hormone releasing hormone (GHRH) (1-29)-NH2 with a mean serum increase of 10.7 ng/ml growth hormone (GH) (range 2.5-29.3 ng/ml). Continuous s.c.
B Staudt, O Butenandt
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General and Comparative Endocrinology, 2013
Pituitary GH is obligatory for normal growth in mammals, but the importance of pituitary GH in avian growth is less certain. In birds, pituitary GH is biologically active and has growth promoting actions in the tibia-test bioassay. Its importance in normal growth is indicated by the growth suppression following the surgical removal of the pituitary ...
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Pituitary GH is obligatory for normal growth in mammals, but the importance of pituitary GH in avian growth is less certain. In birds, pituitary GH is biologically active and has growth promoting actions in the tibia-test bioassay. Its importance in normal growth is indicated by the growth suppression following the surgical removal of the pituitary ...
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2009
Human growth hormone (hGH) is a proteohormone secreted by the pituitary gland. It acts through binding to the hGH receptor, inducing either direct effects or initiating the production of insulin-like growth-factor I (IGF-I), the most important mediator of hGH effects.
Martin, Bidlingmaier +1 more
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Human growth hormone (hGH) is a proteohormone secreted by the pituitary gland. It acts through binding to the hGH receptor, inducing either direct effects or initiating the production of insulin-like growth-factor I (IGF-I), the most important mediator of hGH effects.
Martin, Bidlingmaier +1 more
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Growth hormone- and growth-hormone-releasing hormone-producing tumors
1997Acromegaly, a clinical syndrome of disordered somatic growth and proportion, is usually caused by the unrestrained secretion of growth hormone (GH) by a pituitary adenoma and rarely may result from GH-releasing hormone (GHRH) secretion by an extrapituitary tumor.
Ilan Shimon, Shlomo Melmed
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Growth hormone regulation of growth hormone-releasing hormone gene expression
Peptides, 1988Slot-blot hybridization technique was used to evaluate growth hormone-releasing hormone (GHRH) mRNA levels in the hypothalamus of long-term (14 days) hypophysectomized (HPX) rats treated or not with 125 micrograms hGH/rat, twice daily IP, since the first day postsurgery. In addition, mRNA levels were determined in the hypothalamus of short-term (4 days)
V. De GENNARO COLONNA +4 more
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Interactions of Growth Hormone Secretagogues and Growth Hormone-Releasing Hormone/Somatostatin
Endocrine, 2001The class of novel synthetic compounds termed growth hormone secretagogues (GHSs) act in the hypothalamus through, as yet, unknown pathways. We performed physiologic and histochemical studies to further understand how the GHS system interacts with the well-established somatostatin (SRIF)/growth hormone-releasing hormone (GHRH) neuroendocrine system for
Gloria Shaffer Tannenbaum +1 more
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