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General and Comparative Endocrinology, 2013
Pituitary GH is obligatory for normal growth in mammals, but the importance of pituitary GH in avian growth is less certain. In birds, pituitary GH is biologically active and has growth promoting actions in the tibia-test bioassay. Its importance in normal growth is indicated by the growth suppression following the surgical removal of the pituitary ...
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Pituitary GH is obligatory for normal growth in mammals, but the importance of pituitary GH in avian growth is less certain. In birds, pituitary GH is biologically active and has growth promoting actions in the tibia-test bioassay. Its importance in normal growth is indicated by the growth suppression following the surgical removal of the pituitary ...
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2009
Human growth hormone (hGH) is a proteohormone secreted by the pituitary gland. It acts through binding to the hGH receptor, inducing either direct effects or initiating the production of insulin-like growth-factor I (IGF-I), the most important mediator of hGH effects.
Martin, Bidlingmaier+1 more
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Human growth hormone (hGH) is a proteohormone secreted by the pituitary gland. It acts through binding to the hGH receptor, inducing either direct effects or initiating the production of insulin-like growth-factor I (IGF-I), the most important mediator of hGH effects.
Martin, Bidlingmaier+1 more
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Growth hormone- and growth-hormone-releasing hormone-producing tumors
1997Acromegaly, a clinical syndrome of disordered somatic growth and proportion, is usually caused by the unrestrained secretion of growth hormone (GH) by a pituitary adenoma and rarely may result from GH-releasing hormone (GHRH) secretion by an extrapituitary tumor.
Ilan Shimon, Shlomo Melmed
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Growth hormone regulation of growth hormone-releasing hormone gene expression
Peptides, 1988Slot-blot hybridization technique was used to evaluate growth hormone-releasing hormone (GHRH) mRNA levels in the hypothalamus of long-term (14 days) hypophysectomized (HPX) rats treated or not with 125 micrograms hGH/rat, twice daily IP, since the first day postsurgery. In addition, mRNA levels were determined in the hypothalamus of short-term (4 days)
V. De GENNARO COLONNA+4 more
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Interactions of Growth Hormone Secretagogues and Growth Hormone-Releasing Hormone/Somatostatin
Endocrine, 2001The class of novel synthetic compounds termed growth hormone secretagogues (GHSs) act in the hypothalamus through, as yet, unknown pathways. We performed physiologic and histochemical studies to further understand how the GHS system interacts with the well-established somatostatin (SRIF)/growth hormone-releasing hormone (GHRH) neuroendocrine system for
Gloria Shaffer Tannenbaum+1 more
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Growth hormone response to growth hormone-releasing hormone and clonidine in depression
Biological Psychiatry, 1995Growth hormone (GH) responses to the alpha 2-adrenoceptor agonist clonidine and to GH-releasing hormone (GHRH) were measured in 12 patients fulfilling DSM-III-R criteria for major depressive disorder and in 12 age- and sex-matched controls. GH responses to clonidine correlated significantly with the GH responses to GHRH in the depressed patients as ...
Gann, Horst J.+4 more
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Growth Hormone-Releasing Hormone and Growth Hormone Secretagogues in Normal Aging
Endocrine, 2003Growth hormone (GH) secretion declines with aging, and parallels between normal aging and the signs and symptoms of adult GH deficiency have led to interest in the potential utility of replacing or stimulating GH to promote physical and psychological function and to prolong the capacity for independent living in older adults.
George R. Merriam+3 more
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Growth hormone response to growth hormone releasing hormone in depression and schizophrenia
Psychiatry Research, 1990Growth hormone releasing hormone, a 44-amino acid peptide (GHRH-44), was administered (1 micrograms/kg i.v.) to 6 normal controls, 10 schizophrenic subjects, and 7 depressed subjects. A significantly lower growth hormone (GH) response was found in the schizophrenic and depressed groups.
Edith Markoff+5 more
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Sex differences in growth hormone response to growth hormone-releasing hormone
Journal of Endocrinological Investigation, 1991The aim of the present study was to ascertain whether sex differences exist in GH response to GHRH, and the influence that menstrual cycle have on this response. A GHRH test was performed on nine healthy men and ten women on days one and twelve of the menstrual cycle.
Lucinda Cacicedo+5 more
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Growth Hormone Responses to Continuous Infusions of Growth Hormone-Releasing Hormone*
The Journal of Clinical Endocrinology & Metabolism, 1985The pattern of GH secretion during a continuous 4-h iv infusion of 1 microgram/kg.h GH-releasing hormone (1-44)-NH2 (GHRH-44) or saline was examined in 15 adult men. There was prompt release of GH beginning within 20 min of starting the GHRH-44 infusions, reaching peak GH levels of 43 +/- 11 (+/- SE) ng/ml within 60-90 min.
D. Lynn Loriaux+7 more
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