Results 91 to 100 of about 304,424 (378)

Congenital Hypopituitarism During the Neonatal Period: Epidemiology, Pathogenesis, Therapeutic Options, and Outcome [PDF]

, 2021
INTRODUCTION: Congenital hypopituitarism (CH) is characterized by a deficiency of one or more pituitary hormones. The pituitary gland is a central regulator of growth, metabolism, and reproduction.
Bosch i Ara, L, Dattani, MT, Katugampola, H   +2 more
core  

Time, the final frontier

Molecular Oncology, EarlyView.
This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain, Michal Dibus, Omkar Joshi, Guillaume Jacquemet   +3 more
wiley   +1 more source

Utilizing of protein splicing phenomenon for optimization of obtaining and purification of the recombinant human growth hormone [PDF]

Europ J Medic Res., 2006, Oct. 8, vol.11 - p. 128-129, 2006
Protein splicing is a post-translational autocatalystic excision of internal protein sequence (intein) with the subsequent ligation of the flanking polypeptides (exteins). The high specificity of excision ensured by intein makes it possible to use a phenomenon of protein splicing for the biotechnology purposes.
arxiv  

Aged PROP1 Deficient Dwarf Mice Maintain ACTH Production [PDF]

, 2011
Humans with PROP1 mutations have multiple pituitary hormone deficiencies (MPHD) that typically advance from growth insufficiency diagnosed in infancy to include more severe growth hormone (GH) deficiency and progressive reduction in other anterior ...
A Bottner, A Markowska, A Sadeghi-Nejad, AM Procter, Amanda H. Mortensen, AP Coll, B Andersen, BB Mendonca, C Fluck, CA Stratakis, Catherine E. Keegan, CL Coulter, D Kelberman, David L. Bavers, F Beuschlein, F Lupu, F Pernasetti, Felix Beuschlein, FG Riepe, G Agarwal, Gary D. Hammer, Giovambattista Pani, GP Chrousos, GP Chrousos, GV Vimpani, H Gotoh, HK Ghayee, HL Burrows, HM Brown-Borg, Igor O. Nasonkin, IJ Karolyi, IO Nasonkin, J Cogan, JC Job, JG Shire, JL Mills, JO Scheys, JR Lindsay, JS Parks, K Hussain, K Ohta, K Tang, KE Borg, KT Coschigano, L Hershkovitz, L Zhang, M Roux, ML Sobrier, MS Buckwalter, MW Sornson, PJ Gage, PJ Gage, PS Babu, PV Holmes, RD Ward, RD Ward, Robert D. Ward, RP Piekorz, RW Pfäffle, S George, S Mesiano, S Radovick, Sally A. Camper, SM Black, SP Taback, W Wu, X Wang, Z Laron   +67 more
core   +3 more sources

Adenosine A3 receptor antagonists as anti‐tumor treatment in human prostate cancer: an in vitro study

FEBS Open Bio, EarlyView.
The A3 adenosine receptors (A3ARs) are overexpressed in prostate cancer. AR 292 and AR 357, as A3AR antagonists, are capable of blocking proliferation, modulating the expression of drug transporter genes involved in chemoresistance, ferroptosis, and the hypoxia response, and inducing cell death.
Maria Beatrice Morelli, Andrea Spinaci, Cui Chang, Rosaria Volpini, Catia Lambertucci, Matteo Landriscina, Vincenza Conteduca, Consuelo Amantini, Cristina Aguzzi, Laura Zeppa, Martina Giangrossi, Laura Soverchia, Matteo Santoni, Massimo Nabissi, Giorgio Santoni, Carlo Polidori   +15 more
wiley   +1 more source

Growth hormone: beyond growth:The growth hormone/insulin-like growth factor-1 axis in healthy elderly, growth hormone deficient adults and adults with Prader-Willi Syndrome [PDF]

Outline of this thesis General introduction Chapter 1, the general introduction and first part of this thesis, consists of an introduction that provides more background on the regulation of growth hormone secretion and the growth hormone/insulin-like ...
van Nieuwpoort, Ingrid Caroline
core   +1 more source

Pituitary stalk interruption syndrome presenting in a euthyroid adult with short stature [PDF]

, 2018
Pituitary stalk interruption syndrome (PSIS) is a distinct and rare clinical entity responsible for congenital hypopituitarism resulting in deficiency of pituitary hormones with deficiency of the growth hormone (100%) and gonadotropins (97.2%) being its ...
Azeemuddin, Muhammad, Nawaz, Atif, Shahid, Jehanzeb   +2 more
core   +2 more sources

Adult Growth Hormone Deficiency

Apollo Medicine, 2009
Growth Hormone Deficiency (GHD) can persist from childhood or be newly acquired. Confirmation through stimulation testing is usually required unless there is a proven genetic/structural lesion persistent from childhood. Growth harmone (GH) therapy offers benefits in body composition, exercise capacity, skeletal integrity, and quality of life measures ...
Mukul Gupta, Niti Agrawal, Subhash Kumar Wangnoo   +2 more
openaire   +2 more sources

Possible role of human ribonuclease dicer in the regulation of R loops

FEBS Open Bio, EarlyView.
R loops play an important role in regulating key cellular processes such as replication, transcription, centromere stabilization, or control of telomere length. However, the unscheduled accumulation of R loops can cause many diseases, including cancer, and neurodegenerative or inflammatory disorders. Interestingly, accumulating data indicate a possible
Klaudia Wojcik, Paulina Krzeminska, Anna Kurzynska‐Kokorniak   +2 more
wiley   +1 more source

X-linked agammaglobulinemia and isolated growth hormone deficiency

The Turkish Journal of Pediatrics, 1998
X-linked agammaglobulinemia and isolated growth hormone deficiency was first described in 1980 and then classified as a different primary immune deficiency.
D Arslan, T Patiroğlu, M Kendirci, S Kurtoğlu   +3 more
doaj