Results 81 to 90 of about 5,767,757 (296)

Isolated growth hormone deficiency type 2: from gene to therapy

, 2012
Isolated growth hormone deficiency type-2 (IGHD-2), the autosomal-dominant form of GH deficiency, is mainly caused by specific splicing mutations in the human growth hormone (hGH) gene (GH-1).
Vibor Pektovic, Lochmatter, Didier, Maria Consolata Miletta, Didier Lochmatter, Pektovic, Vibor, Primus-E. Mullis, Miletta, Maria Consolata, Mullis, Primus-E   +7 more
core   +1 more source

Natural history of growth hormone deficiency in a pediatric cohort. [PDF]

, 2015
BACKGROUND/AIMS Controversies still exist regarding the evaluation of growth hormone deficiency (GHD) in childhood at the end of growth. The aim of this study was to describe the natural history of GHD in a pediatric cohort.
Pitteloud, Nelly, Faouzi, Mohamed, Theintz, Gerald E, Elowe-Gruau, Eglantine, Dwyer, Andrew, Stoppa-Vaucher, Sophie, Phan-Hug, Franziska, Deillon, Eva, Dubuis, Jean-Michel, Mullis, Primus-Eugen, Hauschild, Michael   +10 more
core   +2 more sources

Growth hormone in growth hormone deficiency [PDF]

BMJ, 2002
  +6 more sources

CROSS-TALK BETWEEN ENDOCRINE SYSTEM AND OTHER BIOLOGICAL PATHWAYS: PHYSIOLOGICAL AND PATHOLOGICAL IMPLICATIONS IN PAEDIATRIC ENDOCRINOPATHIES [PDF]

, 2009
Endocrine system exerts relevant effects on multiple organs and tissues. Pleiotropic and redundant functions of circulating hormones are due to the various receptors expressed on multiple target cells.
Capalbo, Donatella
core   +1 more source

Discontinuation of long-term growth hormone treatment in adults with growth hormone deficiency: a survey of UK practice

Endocrine Connections
Objective: We conducted a survey of UK endocrine clinicians between June 2022 and August 2022 to understand current practices regarding GH treatment discontinuation in adults with growth hormone deficiency.
Sherwin Criseno, Helena Gleeson, Andrew A Toogood, Neil Gittoes, Anne Topping, Niki Karavitaki   +5 more
doaj   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Insulin sensitivity in adults with growth hormone deficiency and effect of growth hormone treatment

, 2005
Adult growth hormone deficiency (GHD) is a multifactorial disorder in which pituitary dysfunction associated with pituitary adenomas or their treatment plays a major role.
Bramnert, Margareta,, Segerlantz, Mikael,, Lund University., Groop, Leif,   +3 more
core   +1 more source

Circulating microRNA signatures of cachexia and cancer in Canis familiaris as a comparative oncology model for human disease

Molecular Oncology, EarlyView.
Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park, Kyongman An, Gyeonghwa Kim, Soo‐Nyun Choi, Hong‐Ki Lee, Keun Hur, Kyu‐Shik Jeong   +6 more
wiley   +1 more source

Growth hormone deficiency in adulthood and the effects of growth hormone replacement: a review. Growth Hormone Research Society Scientific Committee [PDF]

, 1998
"GH DEFICIENCY in the human adult most commonly results from pituitary or peripituitary tumors and their treatment (1). The majority of these tumors are benign, and in a large series, pituitary adenoma was the commonest cause of adult hypopituitarism (2).
Tanaka, T, Sonksen, P.H., Christiansen, J.S., Hintz, R., Thorner, M., Bengtsson, B A, Laron, Z., Clemmons, D, Ho, K., Carlsson, L., Sizonenko, P, Christ, E R, Hintz, R, Sönksen, P H, Carlsson, L, Carroll, P V, Sizonenko, P., Tanaka, T., Carroll, Paul V., Laron, Z, Thorne, M, Sizonenko, Pierre-Claude, Christiansen, J S, Ho, K, Clemmons, David, Christ, Emanuel R., Bengtsson, B.A.   +26 more
core   +2 more sources

Frequency of Growth Hormone Deficiency in Children with Short Stature

مجله دانشکده پزشکی اصفهان, 2010
Background: Growth hormone deficiency is an important and treatable cause for short stature in early diagnosed cases. This study was conducted to determine the frequency of growth hormone deficiency in children with short stature referred. Methods:
Shideh Assar, Hajieh Shahbazian, Kourosh Riahi, Keramat Kheradmand   +3 more
doaj