Results 1 to 10 of about 404,678 (309)

Optimization of production of recombinant human growth hormone in Escherichia coli

Journal of Research in Medical Sciences, 2012
Background: Human growth hormone (hGH) is a single-chain polypeptide that participates in a wide range of biological functions such as metabolism of proteins, carbohydrates and lipids as well as in growth, development and immunity.
Marzieh Rezaei, Sayyed H Zarkesh-Esfahani   +1 more
doaj  

Recombinant growth hormone for children with systemic lupus erythematosus and linear growth delay: A report of two cases and literature review

Journal of International Medical Research
Linear growth delay is common in children with systemic lupus erythematosus. There have been scattered reports of using recombinant human growth hormone in these children, but safety remains a major concern.
Fujuan Liu, Xiaoying Yuan, Yanjun Yang, Yanan Han, Lanlan Ge, Jingxiao Guo, Ling Liu, Chunzhen Li, Dongfeng Zhang   +8 more
doaj   +1 more source

Quality of Life of Short-Statured Children Born Small for Gestational Age or Idiopathic Growth Hormone Deficiency Within 1 Year of Growth Hormone Treatment

Frontiers in Pediatrics, 2019
Aside from clinical endpoints like height gain, health-related quality of life has also become an important outcome indicator in the medical field. However, the data on short stature and health-related quality of life is inconsistent.
Julia Quitmann, Janika Bloemeke, Neuza Silva, Neuza Silva, Monika Bullinger, Stefanie Witt, Ilker Akkurt, Desiree Dunstheimer, Christian Vogel, Volker Böttcher, Ursula Kuhnle Krahl, Markus Bettendorf, Eckhard Schönau, Susanne Fricke-Otto, Alexandra Keller, Klaus Mohnike, Helmuth-Günther Dörr   +16 more
doaj   +1 more source

The Molecular Properties of Human Growth Hormone

Journal of Biological Chemistry, 1972
Abstract The stability of human growth hormone to acid, alkali, and urea has been evaluated by fluorescence, absorption, and circular dichroism spectroscopy. In accord with previous studies on other growth hormones and prolactins, similar molecular transitions were observed although small shifts in parameters were found among the different proteins. It
ALOJ, SALVATORE MARIA, EDELHOCH H.
openaire   +3 more sources

Delphi-based Spanish consensus on the use of long-acting growth hormone in pediatric growth hormone deficiency: recommendations from the ConverGHe Working Group

Frontiers in Endocrinology
BackgroundLong-acting growth hormone (LAGH) formulations have emerged as an alternative to daily recombinant human growth hormone (rhGH) in pediatric growth hormone deficiency (GHD).
Lidia Castro-Feijóo, José-Ignacio Labarta-Aizpún, Marta Ramon-Krauel, Diana Primiano, Diego Yeste Fernández, Isabel González Casado   +5 more
doaj   +1 more source

Antagonists of Growth Hormone-Releasing Hormone Inhibit the Growth of U-87MG Human Glioblastoma in Nude Mice

Neoplasia: An International Journal for Oncology Research, 2000
Antagonists of growth hormone-releasing hormone(GH-RH) inhibit the growth of various cancers by mechanisms that involve the suppression of the insulin-like growth factor (IGF) -I and/or IGF-II.
Hippokratis Kiaris, Andrew V. Schally, Jozsef L. Varga   +2 more
doaj   +1 more source

Growth hormone and aging: a clinical review

Frontiers in Aging
Aging is a complex biological process characterized by functional decline, reduced quality of life, and increased vulnerability to diseases such as type 2 diabetes, cardiovascular conditions, neurodegeneration, and cancer.
Luis E. Fernández-Garza, Luis E. Fernández-Garza, Luis E. Fernández-Garza, Fernando Guillen-Silva, Fernando Guillen-Silva, Marcos A. Sotelo-Ibarra, Marcos A. Sotelo-Ibarra, Andrés Ely Domínguez-Mendoza, Silvia A. Barrera-Barrera, Hugo A. Barrera-Saldaña, Hugo A. Barrera-Saldaña, Hugo A. Barrera-Saldaña, Hugo A. Barrera-Saldaña, Hugo A. Barrera-Saldaña   +13 more
doaj   +1 more source

Structural basis for activation of the growth hormone-releasing hormone receptor

Nature Communications, 2020
Growth hormone-releasing hormone (GHRH) controls metabolism and tissue growth through binding to the cognate receptor (GHRHR). Here authors report the structure of the human GHRHR bound to its endogenous ligand and the stimulatory G protein which reveals
Fulai Zhou, Huibing Zhang, Zhaotong Cong, Li-Hua Zhao, Qingtong Zhou, Chunyou Mao, Xi Cheng, Dan-Dan Shen, Xiaoqing Cai, Cheng Ma, Yuzhe Wang, Antao Dai, Yan Zhou, Wen Sun, Fenghui Zhao, Suwen Zhao, Hualiang Jiang, Yi Jiang, Dehua Yang, H. Eric Xu, Yan Zhang, Ming-Wei Wang   +21 more
doaj   +1 more source

Sleep deprivation and diet affect human GH gene expression in transgenic mice in vivo

Endocrine Connections, 2020
Human (h) growth hormone (GH) production studies are largely li mited to effects on secretion. How pituitary hGH gene (hGH-N/GH1) expression is regulated is important in our understanding of the role hGH plays in physiology and disease.
Jessica S Jarmasz, Yan JinYan Jin, Hana Vakili, Peter A Cattini   +3 more
doaj   +1 more source

Growth Hormone Therapy in Children with Chronic Renal Failure

Eurasian Journal of Medicine, 2019
Growth is impaired in a chronic renal failure. Anemia, acidosis, reduced intake of calories and protein, decreased synthesis of vitamin D and increased parathyroid hormone levels, hyperphosphatemia, renal osteodystrophy and changes in growth hormone ...
Atilla Cayir, Celalettin Kosan
doaj   +1 more source