Results 31 to 40 of about 1,820,127 (391)

PEGylated Recombinant Human Growth Hormone Jintrolong® Exhibits Good Long-Term Safety in Cynomolgus Monkeys and Human Pediatric Growth Hormone Deficiency Patients

Frontiers in Endocrinology, 2022
Jintrolong® is a long-acting PEGylated recombinant human growth hormone (PEG-rhGH) developed for weekly injection in patients with pediatric growth hormone deficiency (PGHD). Although PEG modification of therapeutic proteins is generally considered safe,
Wei Wu, Juan Zhou, Chuandong Wu, Qian Zhou, Xiaoyu Li, Yanlin Zhang, Conglin Zuo, Jun Yin, Ling Hou, Shuyang Wang, Hongyang Gao, Tianhong Luo, Lei Jin, Enhong Zhong, Yingwu Wang, Xiaoping Luo   +15 more
doaj   +1 more source

Growth Hormone (GH)-Releasing Peptide Stimulation of GH Release from Human Somatotroph Adenoma Cells: Interaction with GH-Releasing Hormone, Thyrotropin- Releasing Hormone, and Octreotide. [PDF]

, 1994
The synthetic hexapeptide GH-releasing peptide (GHRP; His-D-Trp-Ala-Trp-D-Phe-Lys-NH2) specifically stimulates GH secretion in humans in vivo and in animals in vitro and in vivo via a still unknown receptor and mechanism.
Brockmeier, S., Lange, M., Müller, Otto-Albrecht, Renner, U., Schopohl, Jochen, Stalla, G. K., Strasburger, Christian J., Werder, K. von   +7 more
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Effects of recombinant human growth hormone administration on cardiovascular risk factors in obese children with relative growth hormone deficiency

Lipids in Health and Disease, 2018
Background Based on the sample of obese children with relative growth hormone deficiency (GHD), the objective of our study was to determine the effects of rhGH treatment on cardiovascular risk factors, including body mass index (BMI), lipid levels and ...
Shuang Liang, Jiang Xue, Guimei Li
doaj   +1 more source

Harmonization of growth hormone measurements with different immunoassays by data adjustment [PDF]

, 2011
Background: The aim of our study was to evaluate the between-assay variability of commercially available immunoassays for the measurement of human growth hormone (hGH).
Bidlingmaier, Martin, Binder, Gerhard, Blankenstein, Oliver, Heider, Annegret, Kiess, Wieland, Kratzsch, Jürgen, Körner, Antje, Müller, Anne, Pfäffle, Roland, Scholz, Markus, Thiery, Joachim   +10 more
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Influence of autocrine growth hormone on NF-κB activation leading to epithelial–mesenchymal transition of mammary carcinoma

Tumor Biology, 2017
Progression of breast cancers often depends on hormones among which human growth hormone is prominently involved in breast cancer progression. Earlier studies have reported constitutive activation of nuclear factor-κB, a key regulator of growth hormone ...
Srinivas Baskari, Suresh Govatati, Vijaya Madhuri, Nayudu Nallabelli, Paul Marx K, Srinivas Naik, Poornachandar, Swarna Balka, Raghava Rao Tamanam, Venkata Ramana Devi   +9 more
doaj   +1 more source

Growth Hormone Research Society Workshop Summary: Consensus Guidelines for Recombinant Human Growth Hormone Therapy in Prader-Willi Syndrome

Journal of Clinical Endocrinology and Metabolism, 2013
Context: Recombinant human GH (rhGH) therapy in Prader-Willi syndrome (PWS) has been used by the medical community and advocated by parental support groups since its approval in the United States in 2000 and in Europe in 2001. Its use in PWS represents a
C. Deal, Michèle Tony, C. Höybye, D. Allen, M. Tauber, J. Christiansen, G. Ambler, R. Battista, V. Beauloye, G. Berall, B. Biller, M. Butler, S. Cassidy, K. Chihara, P. Cohen, M. Craig, S. Farholt, M. Goetghebeur, A. Goldstone, T. Greggi, G. Grugni, A. Hokken-Koelega, G. Johannsson, Keegan S Johnson, Alex Kemper, J. Kopchick, S. Malozowski, Jennifer Miller, H. Mogul, F. Muscatelli, R. Nergårdh, R. Nicholls, S. Radovick, M. Rosenthal, I. Sipilä, J. Tarride, A. Vogels, M. Waters   +37 more
semanticscholar   +1 more source

Parameters Used for Evaluation of the Response to Treatment with Recombinant Human Growth Hormone in Paediatric and Adult Populations in Poland: Review

Journal of Education, Health and Sport
Introduction and purpose  Recombinant human growth hormone (rhGH) therapy has been the standard treatment  for paediatric short stature for many years, and a therapeutic option for the replacement therapy of growth hormone deficiency in the post ...
Agata Kotkowiak, Mikołaj Łabuda, Agnieszka Szema , Jakub Sikora, Karolina Knychalska, Klaudia Królikowska, Aleksandra Słojewska, Teresa Sowińska, Oliwia Mentel, Adrianna Bogucka   +9 more
doaj   +1 more source

Effects of human recombinant growth hormone on exercise capacity, cardiac structure, and cardiac function in patients with adult-onset growth hormone deficiency [PDF]

, 2017
Objective Epidemiological studies suggest that adult-onset growth hormone deficiency (AGHD) might increase the risk of death from cardiovascular causes. Methods This was a 6-month double-blind, placebo-controlled, randomised, cross-over trial followed by
Atkin, S. L., Atkin, Stephen, Clark, AL, Clark, Andrew, Gonzalez, S., Gonzalez, Susana, Javed, Z., Javed, Zeeshan, Sathyapalan, T., Sathyapalan, Thozhukat, Windram, Hull, Windram, J. D.   +11 more
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Human Growth Hormone

Contemporary endocrinology, 2000
Roy G. Smith, Michael O. Thorner
semanticscholar   +3 more sources

Vascular endothelial growth factor production and regulation in rodent and human pituitary tumor cells in vitro [PDF]

, 2001
Angiogenesis, the formation of a new blood supply, is an essential step in tumorigenesis. Although vascular endothelial growth factor (VEGF) is known to be a very potent angiogenic factor in most solid tumors, little is known about its production and ...
Gloddek, Jutta, Hopfner, Ursula, Lohrer, Penny, Losa, Marco, Pagotto, Uberto, Renner, Ulrich, Stalla, Günter K., Uhl, Eberhard   +7 more
core   +1 more source