Novel RAD50 variants lead to Nijmegen Breakage Syndrome–like disorder and unplanned recombinant human growth hormone treatment response [PDF]
Frontiers in EndocrinologyBackgroundHuman RAD50 gene mutations cause Nijmegen Breakage Syndrome-like disease, characterized by severe prenatal and postpartum growth retardation and microcephaly.
Yan Gong +4 more
doaj +2 more sources
Nutritional Counseling in Children with Growth Hormone Deficiency Treated with Recombinant Human Growth Hormone: Analysis of Growth Response Parameters [PDF]
BiomedicinesBackground and Objectives: Growth failure is the main symptom of growth hormone deficiency (GHD) in children. The standard treatment for GHD is the administration of recombinant human growth hormone (rhGH).
Joanna Budzulak +2 more
doaj +2 more sources
Comparison between long-acting pegylated and daily recombinant human growth hormone for pediatric growth hormone deficiency a systematic review [PDF]
Scientific ReportsThis systematic review aims to summarize the therapeutic benefits and safety profile of long-acting PEGylated recombinant human growth hormone (PEG‑rhGH) compared with daily recombinant human growth hormone (DGH) in pediatric growth hormone deficiency ...
Jun Zhang +3 more
doaj +2 more sources
Diagnosis and recombinant human growth hormone treatment of Wiedemann–Steiner syndrome: discovery of novel KMT2A variants and review of existing literature [PDF]
BMC PediatricsPurpose Wiedemann–Steiner syndrome (WDSTS) is an autosomal dominant disorder with broad and variable phenotypes including short stature. This study aims to determine the long-term effect of recombinant human growth hormone (rhGH) treatment on WDSTS and ...
Mengqin Wang +10 more
doaj +2 more sources
Recombinant human growth hormone treatment of Floating-Harbor syndrome: a case report and literature review [PDF]
BMC PediatricsBackground Floating Harbor syndrome (FHS) is a rare genetic disorder with over 100 reported cases worldwide and less than 30 treated with recombinant human growth hormone (rhGH).
Qing He +5 more
doaj +2 more sources
European Journal of Inflammation, 2019 This study aims to investigate the effects of recombinant human growth hormone (rhGH) on serum nesfatin-1 and ghrelin in children with growth hormone deficiency (GHD), in order to provide a reliable basis for the effectiveness and safety of applying rhGH
Yu Wang +3 more
doaj +2 more sources
Effectiveness of Recombinant Human Growth Hormone for Pharyngocutaneous Fistula Closure [PDF]
Clinical and Experimental Otorhinolaryngology, 2015 ObjectivesIn laryngeal cancer, which comprises 25% of head and neck cancer, chemotherapy has come into prominence with the increase in organ-protective treatments.
Nurten Kucuk +5 more
doaj +1 more source
Laron syndrome: An experience of treatment of two cases
Journal of Clinical and Translational Endocrinology Case Reports, 2021 Laron syndrome or growth hormone insensitivity is a rare disease presenting with severe postnatal growth failure. Clinically, in most circumstances, it is indistinguishable from growth hormone deficiency.
Hiya Boro +4 more
doaj +1 more source
Adverse events of replacement therapy in children with growth hormone deficiency
Zdorovʹe Rebenka, 2023 Background. The purpose was to analyze and summarize the accumulated short-term and long-term safety data in children with growth hormone deficiency (GHD) treated using recombіnant human growth hormone (rhGH) based on the results of a physical ...
M. Aryayev, L. Senkivska
doaj +1 more source
Vitamin D and Parathyroid Hormone during Growth Hormone Treatment
Children, 2022 Background. There is some controversy concerning a potential interaction between vitamin D and PTH and the GH/IGF-1 axis. The goal of this study is to assess vitamin D and PTH status in children with GH deficiency at diagnostic and during treatment with ...
Teodoro Durá-Travé +1 more
doaj +1 more source