Results 21 to 30 of about 12,905,954 (250)

Human growth hormone produced with recombinant DNA technology [PDF]

BIO Web of Conferences
Hormones affect the metabolism by stimulating the genetic apparatus of the cell, activating enzymes and changing the rate of enzymatic reactions. They increase the formation of informative ribonucleic acid, which determines the structure of the protein ...
Mustafakulov Muhammad, Uralov Abdumannon, Ahmedova Sobira, Saidov Zukhriddin   +3 more
doaj   +1 more source

Interaction of Human Chorionic Gonadotropin (hCG) and Asialo-hCG with Recombinant Human Thyrotropin Receptor. [PDF]

, 1994
hCG is a putative thyroid stimulator. The present studies were undertaken to examine its interaction and that of its desialylated variant asialo-hCG with recombinant human TSH (hTSH) receptor (hTSHr). To this end, we transfected a human thyroid carcinoma
Mann, K., Grossmann, M., Derwahl, M., Hoermann, R., Broecker, M.   +4 more
core   +1 more source

Transgenic fish and aquaculture [PDF]

, 1995
Transgenic fish species can be routinely produced by transferring foreign DNA into developing embryos via microinjection or electroporation. This technology offers an excellent opportunity for modifying or improving the genetic traits of commercially ...
Chen, Thomas T.
core   +1 more source

Effects of recombinant human growth hormone administration on cardiovascular risk factors in obese children with relative growth hormone deficiency

Lipids in Health and Disease, 2018
Background Based on the sample of obese children with relative growth hormone deficiency (GHD), the objective of our study was to determine the effects of rhGH treatment on cardiovascular risk factors, including body mass index (BMI), lipid levels and ...
Shuang Liang, Jiang Xue, Guimei Li
doaj   +1 more source

Harmonization of growth hormone measurements with different immunoassays by data adjustment [PDF]

, 2011
Background: The aim of our study was to evaluate the between-assay variability of commercially available immunoassays for the measurement of human growth hormone (hGH).
Bidlingmaier, Martin, Oliver Blankenstein, Jürgen Kratzsch, Körner, Antje, Wieland Kiess, Anne Müller, Markus Scholz, Antje Körner, Thiery, Joachim, Martin Bidlingmaier, Müller, Anne, Scholz, Markus, Blankenstein, Oliver, Annegret Heider, Roland Pfäffle, Joachim Thiery, Heider, Annegret, Kratzsch, Jürgen, Gerhard Binder, Pfäffle, Roland, Binder, Gerhard, Kiess, Wieland   +21 more
core   +1 more source

Long-term response to recombinant human growth hormone therapy in Indian children with growth hormone deficiency

Indian Journal of Endocrinology and Metabolism, 2019
Background: Growth hormone deficiency (GHD) remains the most common indication for use of recombinant human growth hormone (rhGH) therapy in clinical practice.
Monita Gahlot, Alpesh Goyal, Arun K C. Singh, Viveka P Jyotsna, Nandita Gupta, Rajesh Khadgawat   +5 more
doaj   +1 more source

Ten years' clinical experience with biosimilar human growth hormone: a review of efficacy data [PDF]

, 2017
In 2006, the European Medicines Agency (EMA) approved Omnitrope(®) as a biosimilar recombinant human growth hormone (rhGH), on the basis of comparable quality, safety, and efficacy to the reference medicine (Genotropin(®), Pfizer).
Zabransky, Markus, Szalecki, Mieczyslaw, Markus Zabransky, Höbel, Nadja, Pfäffle, Roland, Juan Pedro López-Siguero, Mieczyslaw Szalecki, Chanson, Philippe, Philippe Chanson, Nadja Höbel, López-Siguero, Juan Pedro, Roland Pfäffle   +11 more
core   +1 more source

RESPONSE OF RECOMBINANT HUMAN GROWTH HORMONE IN ISOLATED GROWTH HORMONE DEFICIENCY

Pakistan Armed Forces Medical Journal, 2007
Objective: To observe the response of growth hormone in isolated growth hormone deficiency. Moreover the response was compared when treatment was initiated earlier or later in childhood. Design: Quasi experimental study.
Shahid Aziz, Salman Ali, Uzair Maqsood, Mehboob Sultan, Shahida Badshah   +4 more
doaj   +2 more sources

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

Insulin-like growth factor-I treatment in primary growth hormone insensitivity: effect of recombinant human IGF-I (rhIGF-I) and rhIGF-I/rhIGF-binding protein-3 complex [PDF]

, 2010
Growth hormone insensitivity syndrome (GHIS) is a rare cause of growth retardation characterized by high serum GH levels, and low serum insulin-like growth factor I (IGF-I) levels associated with a genetic defect of the GH receptor (GHR) as well post-GHR
Flück, C E, Mullis, P E, Tonella, P, Mullis PE, Flück CE, Tonella P, P.-E. Mullis, P. Tonella, C.E. Flück   +8 more
core   +2 more sources