Results 21 to 30 of about 75,972 (251)
Comparison of effectiveness of growth hormone therapy according to disease-causing genes in children with Noonan syndrome [PDF]
Korean Journal of Pediatrics, 2019 Purpose To analyze the growth response to growth hormone (GH) therapy in prepubertal patients with Noonan syndrome (NS) harboring different genetic mutations. Methods Twenty-three patients with prepubertal NS treated at Pusan National University Children’
Kyo Jin Jo +7 more
doaj +1 more source
Human growth hormone produced with recombinant DNA technology [PDF]
BIO Web of ConferencesHormones affect the metabolism by stimulating the genetic apparatus of the cell, activating enzymes and changing the rate of enzymatic reactions. They increase the formation of informative ribonucleic acid, which determines the structure of the protein ...
Mustafakulov Muhammad +3 more
doaj +1 more source
The Separation of Recombinant Human Growth Hormone Variants by UHPLC [PDF]
Journal of Chromatographic Science, 2012 Reversed-phase ultra-high-performance liquid chromatography (RP-UHPLC) was used for the separation of recombinant human growth hormone (rhGH) variants. A bridged ethylene hybrid silica C18 column was used at 37°C. The composition and temperature of the mobile phase were optimized for the separation.
Göran, Karlsson +4 more
openaire +2 more sources
Lipids in Health and Disease, 2018 Background Based on the sample of obese children with relative growth hormone deficiency (GHD), the objective of our study was to determine the effects of rhGH treatment on cardiovascular risk factors, including body mass index (BMI), lipid levels and ...
Shuang Liang, Jiang Xue, Guimei Li
doaj +1 more source
The growzen™ buddy smartphone app to improve adherence in patients receiving recombinant human growth hormone therapy: a retrospective observational study in Argentina. [PDF]
Front Endocrinol (Lausanne)van Dommelen P +6 more
europepmc +2 more sources
Indian Journal of Endocrinology and Metabolism, 2019 Background: Growth hormone deficiency (GHD) remains the most common indication for use of recombinant human growth hormone (rhGH) therapy in clinical practice.
Monita Gahlot +5 more
doaj +1 more source
RESPONSE OF RECOMBINANT HUMAN GROWTH HORMONE IN ISOLATED GROWTH HORMONE DEFICIENCY
Pakistan Armed Forces Medical Journal, 2007 Objective: To observe the response of growth hormone in isolated growth hormone deficiency. Moreover the response was compared when treatment was initiated earlier or later in childhood. Design: Quasi experimental study.
Shahid Aziz +4 more
doaj +2 more sources
SAGE Open Medical Case ReportsWe report three pediatric patients who developed epileptic seizures while receiving recombinant human growth hormone therapy. Case 1 was a 12-year-old girl with a history of febrile seizures and epilepsy whose seizures recurred after discontinuation of ...
Shigeru Nagaki +3 more
doaj +1 more source
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
CEACAM1 participation in breast cancer progression
Molecular Oncology, EarlyView.In invasive breast cancer (BC), CEACAM1 shifts from an apical to a uniform membranous/cytoplasmic pattern, or is lost, as tumors dedifferentiate, inversely tracking the Ki‐67 proliferative index. In MCF‐7 cells, only CEACAM1‐4L suppresses proliferation, repressing cell cycle and growth factor genes.
Mykola Lyndin +3 more
wiley +1 more source