New directions in growth hormone treatment in children [PDF]
Pediatric Endocrinology, Diabetes and MetabolismThis paper reviews clinical-trial evidence on the use of long-acting growth hormone (LAGH) preparations in children. Three LAGH products have been approved in Europe and the United States for paediatric growth hormone deficiency (GHD): lonapegsomatropin,
Renata Stawerska
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Growth hormone treatment in non-growth hormone-deficient children [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2014 Until 1985 growth hormone (GH) was obtained from pituitary extracts, and was available in limited amounts only to treat severe growth hormone deficiency (GHD).
Sandro Loche +3 more
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Final adult height in Korean children with idiopathic growth hormone deficiency after growth hormone treatment [PDF]
Scientific ReportsThis study evaluated final adult height (FAH) outcomes and associated predictive factors in patients with idiopathic growth hormone deficiency (IGHD) treated with recombinant human growth hormone (GH).
Min Hyung Cho +4 more
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Population characteristics of children with short stature and construction of a predictive model for growth hormone treatment efficacy [PDF]
Frontiers in MedicineBackgroundThis study aims to analyze clinical characteristics and treatment patterns among children with short stature, and to develop a predictive model for growth hormone treatment efficacy for clinical reference.MethodsThis was a retrospective cohort ...
Chuanwei Ban +9 more
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The effects of Growth hormone treatment discontinuation in Adults on Metabolic profile, Body composition and quality Of Life (GAMBOL Study) [version 2; peer review: 1 approved, 2 approved with reservations] [PDF]
NIHR Open ResearchBackground In adults, treatment of GHD with daily GH injection has been shown to improve many clinical features associated with GHD. Currently, many adults with GHD receive GH treatment indefinitely.
Niki Karavitaki +2 more
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Noonan Syndrome, Cancer Risk, and Growth Hormone Treatment [PDF]
JCRPECancer may occur in patients with Noonan syndrome (NS). Review of English literature revealed that myeloproliferative diseases are the most prevalent, followed by intracranial tumours.
Korcan Demir, Kübra Yüksek Acınıklı
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Short-term effect of growth hormone treatment in childhood leukemia survivors with growth hormone deficiency [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2022 Purpose Survivors of childhood leukemia are at risk of growth impairment due to intensive chemotherapy and radiation treatments. This study investigated the auxological and biochemical characteristics of childhood leukemia survivors diagnosed with growth
Chungwoo Shin +8 more
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Molecular Basis for Hypochondroplasia in Japan
Endocrines, 2022 Hypochondroplasia is an autosomal dominant genetic disorder due to a heterozygous pathogenic variant of the FGFR3 gene. The early diagnosis of hypochondroplasia is necessary, since growth hormone is effective for improving adult height.
Tomohiro Ishii +8 more
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Vitamin D and Parathyroid Hormone during Growth Hormone Treatment
Children, 2022 Background. There is some controversy concerning a potential interaction between vitamin D and PTH and the GH/IGF-1 axis. The goal of this study is to assess vitamin D and PTH status in children with GH deficiency at diagnostic and during treatment with ...
Teodoro Durá-Travé +1 more
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Time for a general approval of growth hormone treatment in adults with Prader–Willi syndrome
Orphanet Journal of Rare Diseases, 2021 Prader-Willi syndrome (PWS) is a complex, multi-system, neurodevelopmental disorder characterised by neonatal muscular hypotonia, short stature, high risk of obesity, hypogonadism, intellectual disabilities, distinct behavioural/psychiatric problems and ...
Charlotte Höybye +3 more
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