Results 61 to 70 of about 513,834 (341)

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

The rationale and design of TransCon Growth Hormone for the treatment of growth hormone deficiency

Endocrine Connections, 2017
The fundamental challenge of developing a long-acting growth hormone (LAGH) is to create a more convenient growth hormone (GH) dosing profile while retaining the excellent safety, efficacy and tolerability of daily GH.
K. Sprogøe, E. Mortensen, D. Karpf, J. Leff   +3 more
semanticscholar   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source

Ubiquitination of secretory granules promotes their crinophagic degradation in Drosophila

FEBS Letters, EarlyView.
Ubiquitination of secretory granules in Drosophila larval salivary glands is a critical molecular trigger for crinophagy, the lysosomal degradation of unreleased, or low‐quality granules. The E3 ubiquitin ligase Cnot4 is recruited to the surface of secretory granules to induce crinophagy.
Tamás Csizmadia, Anna Dósa, Asha Kiran Maddali, András Jipa, Hajnalka Laczkó‐Dobos, Péter Lőw, Gábor Juhász   +6 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Subtype‐specific enhancer RNAs define transcriptional regulators and prognosis in breast cancers

Molecular Oncology, EarlyView.
This study employed machine learning methodologies to perform the subtype‐specific classification of RNA‐seq data sets, which are mapped on enhancers from TCGA‐derived breast cancer patients. Their integration with gene expression (referred to as ProxCReAM eRNAs) and chromatin accessibility profiles has the potential to identify lineage‐specific and ...
Aamena Y. Patel, Peyman Zarrineh, Nathnael T. Tuffa, Jigar H. Sheth, Sumitra Mohan, Mudassar Iqbal, Sankari Nagarajan   +6 more
wiley   +1 more source

Treatment with long-acting growth hormone: effectiveness and safety

Frontiers in Endocrinology
Long-acting growth hormone (GH) formulations represent a clinically effective alternative to daily recombinant human GH (rhGH) administration, enabling extended dosing intervals and enhancing patient adherence. This approach is particularly beneficial in
Livia Basile, Rossella Cannarella, Rosita A. Condorelli, Francesco Frasca, Aldo E. Calogero, Sandro La Vignera   +5 more
doaj   +1 more source

The Level of C-Reactive Protein in the Blood Plasma of Young Adults with Childhood-Onset Growth Hormone Deficiency

Mìžnarodnij Endokrinologìčnij Žurnal, 2016
The article presents the data on the level of high-sensitivity C-reactive protein in the blood plasma of young adults with growth hormone deficiency that occurred in childhood and persists in adulthood.
O.V. Bolshova, T.O. Tkachova, O.A. Vyshnevska   +2 more
doaj   +1 more source

Effect of growth hormone treatment on children with idiopathic short stature and idiopathic growth hormone deficiency [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2017
PurposeThere are inconsistencies in the results reported in a small number of previous studies into growth hormone (GH) treatment in Korean children with idiopathic short stature (ISS) and idiopathic growth hormone deficiency (IGHD).
Minji Im, Yong-Dae Kim, Heon-Seok Han
doaj   +1 more source

Treatment of growth hormone deficiency in adults

, 2009
BACKGROUND: The Growth Hormone Research Society held a Consensus Workshop in Sydney, Australia, in March 2007 to review advances in the management of growth hormone (GH) deficiency in adults and to update consensus recommendations.
Johannsson, Gudmundur,
core   +1 more source