Results 61 to 70 of about 5,767,757 (296)

Efficacy of growth hormone therapy in adults with childhood-onset growth hormone deficiency [PDF]

Annals of Pediatric Endocrinology & Metabolism, 2014
PurposeGrowth hormone (GH) plays a key role in the regulation of body composition, lipid metabolism, and quality of life in adults with GH deficiency (GHD).
Ja Hye Kim, Ja Hyang Cho, Han-Wook Yoo, Jin-Ho Choi   +3 more
doaj   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Genetic regulation of pituitary gland development in human and mouse [PDF]

, 2009
Normal hypothalamopituitary development is closely related to that of the forebrain and is dependent upon a complex genetic cascade of transcription factors and signaling molecules that may be either intrinsic or extrinsic to the developing Rathke’s ...
Robin Lovell-Badge, Dattani, M. T., Robinson, I. C. A. F., Mehul T. Dattani, Lovell-Badge, R., Karine Rizzoti, Iain C. A. F. Robinson, Rizzoti, K., Kelberman, D., Daniel Kelberman   +9 more
core   +1 more source

Treatment with long-acting growth hormone: effectiveness and safety

Frontiers in Endocrinology
Long-acting growth hormone (GH) formulations represent a clinically effective alternative to daily recombinant human GH (rhGH) administration, enabling extended dosing intervals and enhancing patient adherence. This approach is particularly beneficial in
Livia Basile, Rossella Cannarella, Rosita A. Condorelli, Francesco Frasca, Aldo E. Calogero, Sandro La Vignera   +5 more
doaj   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Growth hormone replacement therapy in adults with growth hormone deficiency improves vascular reactivity

, 1999
Patients with adult growth hormone (GH) deficiency are thought to be of increased risk of cardiovascular disease. Impaired vascular reactivity to endothelium derived nitric oxid (NO) is an early event in the development of atherosclerosis.
Russell-Jones, D L, Christ, E R, Sönksen, P H, Russel-Jones, D L, Chowienczyk, P J   +4 more
core   +1 more source

Autophagy and mitophagy in pancreatic β‐cell homeostasis and their involvement in diabetes pathophysiology

FEBS Letters, EarlyView.
This review focuses on the role of autophagy and mitophagy in maintaining pancreatic β‐cell function and homeostasis. We discuss how genetic defects affecting these pathways contribute to the development of type 1, type 2, monogenic, and gestational diabetes. We further explore their potential as therapeutic targets. Created in BioRender.
Yunkyeong Lee, Mingming Tong, Anna L. Gloyn   +2 more
wiley   +1 more source

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Clinical Features of Transient Growth Hormone Deficiency

, 2023
Background: Most patients with idiopathic growth hormone deficiency (iGHD) in childhood have normal GH stimulation test results in adulthood. The present study aimed to investigate the characteristics and possible etiology of transient iGHD.
Kazuhiro Shimura, Kento Ikegawa, Yuki Sakai, Yukihiro Hasegawa   +3 more
core   +1 more source

Growth Hormone Deficiency in Adults

Endocrinology Research and Practice
Growth hormone deficiency (GHD) is the most frequently occurring pituitary hormone deficiency. Lesions in the hypothalamo-pituitary region and their treatment, pituitary apoplexy, empty sella, Sheehan’s syndrome, traumatic brain injury, infective ...
Emre Urhan, Kursad Unluhizarci, Fahrettin Kelestimur   +2 more
doaj   +1 more source