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Dosing of Growth Hormone in Growth Hormone Deficiency
Hormone Research in Paediatrics, 1999Growth hormone (GH) treatment of GH-deficient (GHD) children is to a certain extent standardized worldwide. Recombinant 22 kDa GH is injected once daily by the subcutaneous route, mostly in the evening. The amount of GH injected (calculated per kg body weight or body surface area, expressed in terms of IU or mg) in prepubertal children mimics the known
M B, Ranke +3 more
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Growth hormone replacement for adult growth hormone deficiency
Expert Opinion on Pharmacotherapy, 2003Growth hormone deficiency (GHD) in childhood causes growth retardation, short stature and significant impairment of adult height. Growth hormone (GH) has been given successfully to these children for > 40 years but only since the introduction of recombinant DNA technology, has enough GH been available for paediatric needs and also for other indications.
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Growth hormone deficiency in children
Pituitary, 2008The foundation for the diagnosis of growth hormone (GH) deficiency in childhood must be auxology, that is, the comparison of the child's growth pattern to that of established norms for gender and ethnicity. It is only in those growing considerably more slowly than average that testing for GHD makes sense. Assessment of laboratory tests, whether static,
Erick J, Richmond, Alan D, Rogol
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Familial isolated growth hormone deficiency
Clinical Genetics, 1981A family is reported with isolated growth hormone deficiency in two children, their mother and, presumably, also in two maternal uncles and their maternal grandmother. Autosomal dominant inheritance is the best explanation. Isolated growth hormone deficiency is apparently a heterogeneous condition, including autosomal dominant, autosomal recessive as ...
H H, van Gelderen, C E, van der Hoog
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Radiation-Induced Growth Hormone Deficiency
Hormone Research in Paediatrics, 2003Deficiency of one or more anterior pituitary hormones may follow treatment with external irradiation when the hypothalamic-pituitary axis falls within the fields of irradiation. Hypopituitarism occurs in patients who receive radiation therapy for pituitary tumours, nasopharyngeal cancer and primary brain tumours, as well as in children who undergo ...
K H, Darzy, S M, Shalet
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Isolated Growth Hormone Deficiency: Immunocytochemistry*
The Journal of Clinical Endocrinology & Metabolism, 1984Light and electron microscopic immunocytochemistry of the pituitary gland of a patient with documented isolated GH deficiency revealed parenchyma rich in GH positive cells. Immunoprecipitate was localized consistently over membrane-enclosed secretory granules whose features were characteristic of those in normal somatotrophs.
J, Schechter, K, Kovacs, D, Rimoin
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Growth hormone deficiency throughout puberty
Journal of Endocrinological Investigation, 1992Growth during puberty does not appear to be the major determinate of final height in isolated GH deficient patients. Early diagnosis and commencement of therapy are probably the most important factors, as reflected by the correlation between final height and height at the onset of puberty.
A, Albanese, R, Stanhope
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Genetics of Growth Hormone Deficiency
Endocrinology and Metabolism Clinics of North America, 2007When a child is not following the normal, predicted growth curve, an evaluation for underlying illness and central nervous system abnormalities is required and appropriate consideration should be given to genetic defects causing growth hormone (GH) deficiency.
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Diagnosis of Growth Hormone Deficiency
2010The diagnosis of growth hormone deficiency (GHD) was essentially a clinical one prior to the advent of radioimmunoassay in the mid-1960s. From this point on both clinical and biochemical serum GH responses to a variety of provocation tests were used to define the condition. The definition of an adequate GH response to stimulation has changed over time,
E A, Webb, M T, Dattani
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