Results 51 to 60 of about 253,125 (355)
Optimizing Patient Management and Adherence for Children Receiving Growth Hormone. [PDF]
, 2017 Poor adherence with growth hormone (GH) therapy has been associated with worse clinical outcomes, which in children relates specifically to their linear growth and loss of quality of life.
Carlo L. Acerini +3 more
core +3 more sources
Molecular Oncology, EarlyView.This article advocates integrating temporal dynamics into cancer research. Rather than relying on static snapshots, researchers should increasingly consider adopting dynamic methods—such as live imaging, temporal omics, and liquid biopsies—to track how tumors evolve over time.
Gautier Follain +3 more
wiley +1 more source
Growth hormone deficiency and cerebral palsy
Therapeutics and Clinical Risk Management, 2010 Jesús Devesa1,2, Nerea Casteleiro2, Cristina Rodicio2, Natalia López2, Pedro Reimunde1,21Department of Physiology, School of Medicine of Santiago de Compostela, Spain; 2Medical Center Proyecto Foltra, 15886 Teo, SpainAbstract ...
Jesús Devesa +3 more
doaj
Effect of growth hormone treatment on children with idiopathic short stature and idiopathic growth hormone deficiency [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2017 PurposeThere are inconsistencies in the results reported in a small number of previous studies into growth hormone (GH) treatment in Korean children with idiopathic short stature (ISS) and idiopathic growth hormone deficiency (IGHD).
Minji Im, Yong-Dae Kim, Heon-Seok Han
doaj +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
Molecular Oncology, EarlyView.TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo +18 more
wiley +1 more source
Intrauterine Zn deficiency favors thyrotropin-releasing hormone-increasing effects on thyrotropin serum levels and induces subclinical hypothyroidism in weaned rats [PDF]
, 2017 Individuals who consume a diet deficient in zinc (Zn-deficient) develop alterations in hypothalamic-pituitary-thyroid axis function, i.e., a low metabolic rate and cold insensitivity.
Alcántara-Alonso, Viridiana +3 more
core +2 more sources
Genomics‐led approach to drug testing in models of undifferentiated pleomorphic sarcoma
Molecular Oncology, EarlyView.GA text Genomic data from undifferentiated pleomorphic sarcoma patients and preclinical models were used to inform a targeted drug screen. Selected compounds were tested in 2D and 3D cultures of UPS cell lines. A combination of trametinib and infigratinib was synergistic in the majority of UPS cell lines tested, which was further confirmed in an ex ...
Piotr J. Manasterski +19 more
wiley +1 more source
Güncel Pediatri, 2010 Growth hormone deficiency is the most promising entity in terms of response to therapy among the treatable causes of growth retardation. It may be due to genetic or acquired causes.
Ömer Tarım, Halil Sağlam
doaj
Mìžnarodnij Endokrinologìčnij Žurnal, 2016 The article presents the data on the level of high-sensitivity C-reactive protein in the blood plasma of young adults with growth hormone deficiency that occurred in childhood and persists in adulthood.
O.V. Bolshova +2 more
doaj +1 more source
Growth hormone treatment in non-growth hormone-deficient children [PDF]
Annals of Pediatric Endocrinology & Metabolism, 2014 Until 1985 growth hormone (GH) was obtained from pituitary extracts, and was available in limited amounts only to treat severe growth hormone deficiency (GHD). With the availability of unlimited quantities of GH obtained from recombinant DNA technology, researchers started to explore new modalities to treat GHD children, as well as to treat a number of
Chiara Guzzetti +3 more
openaire +3 more sources