Results 181 to 190 of about 447,676 (302)

Suprasellar CNS germ cell tumors and endocrine sequelae: early growth hormone therapy as a contributor to height gain: a single institute analysis. [PDF]

Childs Nerv Syst
Suda A, Fukushima H, Takarada A, Suzuki R, Iwabuchi A, Muroi A, Mizumoto M, Takada H.   +7 more
europepmc   +1 more source

GPCRs in CAR‐T Cell Immunotherapy: Expanding the Target Landscape and Enhancing Therapeutic Efficacy

Advanced Science, EarlyView.
Chimeric antigen receptor T cell therapy faces dual challenges of target scarcity and an immunosuppressive microenvironment in solid tumors. This review highlights how G protein‐coupled receptors can serve as both novel targets to expand the therapeutic scope and functional modules to enhance CAR‐T cell efficacy.
Zhuoqun Liu, Yuchen Xiao, Yamin Zhao, Lihe Dai, David J.H. Shih, Shikang Liang, Honglei Tian, Liu Liu, Feng Tian, Bing Liu, Lei Chang, Chao Zhang   +11 more
wiley   +1 more source

Adherence to recombinant human growth hormone therapy in children: influencing factors and clinical implications. [PDF]

Front Pediatr
Chang W, Jin H, Zhou Q, Ye K, Dai Y.
europepmc   +1 more source

Organ‐Specific and Conserved Regulatory Logic Orchestrates Gene Expression in the Embryonic Mesothelium

Advanced Science, EarlyView.
Integrated multi‐omic profiling maps the gene‐regulatory landscape of the coelomic mesothelium across heart, lung, and pancreas. A cardiac‐restricted regulatory program is uncovered in which TBX20 activates heart mesothelial (epicardial) cis‐regulatory elements, while MAF emerges as a conserved regulator of mesothelial identity.
Quang Minh Dang, Nicola Smart, Andia Nicole Redpath, Joaquim Miguel Vieira   +3 more
wiley   +1 more source

The role of digital health in growth hormone therapy: perspectives from Gulf Cooperation Council pediatric endocrinologists. [PDF]

Front Endocrinol (Lausanne)
Kaplan W, Alherbish A, Aljnaibi A, Alsagheir A, Almutair A, Farooque A, Deeb A, Abbas BB, Jubeh JA, Attia N, Thalange N, Salem Al Remeithi S, Dimitri P, Rivera-Romero O, Koledova E.   +14 more
europepmc   +1 more source

Hypersscretion of ACTH growth hormone and prolactin in a patient with pituitary adenoma [PDF]

, 1978
Fink, R., Müller, O. A., Scriba, Peter Christian, Werder, Klaus von   +3 more
core   +1 more source

4‐Hydroxybenzyl Alcohol Mitigates Hyperlipidemia‐Associated Depression by Inhibiting Neuroinflammation via the NKIRAS2/NF‐κB Pathway

Advanced Science, EarlyView.
4‐HBA upregulates NKIRAS2 levels, inhibiting the activation of the NF‐κB pathway and subsequently reducing the levels of neuroinflammatory markers. This modulation helps restore normal mood and behavior in hyperlipidemic conditions, providing a potential therapeutic strategy for managing hyperlipidemia‐associated depression.
Ying Zhang, Meng Teng, Wenxuan He, Lanzhou Li, Yongfeng Zhang, Shimiao Wang, Chunyue Wang, Di Wang   +7 more
wiley   +1 more source

Noonan syndrome spectrum disorders in real life: patient characteristics and response to growth hormone therapy in a genetically defined single-country multicenter cohort. [PDF]

Eur J Pediatr
Jirova B, Najdekova M, Cerna J, Dusatkova P, Holotova K, Kolouskova S, Kotvalova I, Magnova O, Modrak M, Novotna D, Obermannova B, Pavlicek J, Plachy L, Pomahacova R, Pruhova S, Rezabkova J, Strnadel J, Snajderova M, Sumnik Z, Zapletalova J, Lebl J.   +20 more
europepmc   +1 more source

A Functionally Conserved Enhancer is Critical for PGC1A Expression and Thermogenesis in Brown Fat

Advanced Science, EarlyView.
An evolutionarily conserved enhancer controls PGC1A expression and thermogenic activation in brown adipose tissue. Integrative multi‐omics analyses identify two BAT‐specific enhancers, with PGC1A‐En1 functioning as the dominant regulatory element that maintains thermogenic capacity across species.
Duo Su, Haosen Yang, Xiaokai Li, Tingting Jiang, Siyuan Zhan, Tao Zhong, Jiazhong Guo, Yan Wang, Li Li, Hongping Zhang, Linjie Wang   +10 more
wiley   +1 more source

Impact of COVID-19 on growth hormone therapy efficacy in pediatric patients with short stature. [PDF]

Endocr Connect
Kim YM, Oh AR, Han HS, Yu J, Yu J, Lee TK, Lee GM, Choe J, Oh JS, Lim HH.   +9 more
europepmc   +1 more source