Results 71 to 80 of about 447,676 (302)

Evolving growth hormone deficiency: proof of concept

Frontiers in Endocrinology
IntroductionWe present the evolution of GHD in adolescent males with persistent growth failure, in whom the diagnosis was established after a second GH stimulation test (GST).MethodsWe performed a retrospective chart review of children who presented for ...
Sri Nikhita Chimatapu, Swathi Sethuram, Julie G. Samuels, Alexandra Klomhaus, Cassie Mintz, Martin O. Savage, Robert Rapaport   +6 more
doaj   +1 more source

Programmable models of growth and mutation of cancer-cell populations

, 2011
In this paper we propose a systematic approach to construct mathematical models describing populations of cancer-cells at different stages of disease development.
A.M. Ideta, A.R. Rao, Alberto Policriti, C.J. Mode, D. Gillespie, D. J. Wilkinson, D. Skulj, D.T. Gillespie, Erik de Vink, F. Ciocchetta, F. Ciocchetta, F. Ciocchetta, G. Tanaka, H. Hermanns, Ion Petre, J. R. Norris, L. Bortolussi, L. Bortolussi, L. Bortolussi, L. Bortolussi, L. Bortolussi, Luca Bortolussi, M. Ajmone Marsan, M. Bernardo, M. K. Brawer, M.H.A. Davis, P. Lecca, P.A. Abrahamsson, S.K. Jha, T. L. Jackson, T. Mazza   +30 more
core   +2 more sources

Reference Profile Correlation Reveals Estrogen-like Trancriptional Activity of Curcumin [PDF]

, 2010
Background: Several secondary metabolites from herbal nutrient products act as weak estrogens (phytoestrogens), competing with endogenous estrogen for binding to the estrogen receptors and inhibiting steroid converting enzymes.
Albini, Adriana, Bachmeier, Beatrice E., Blengio, Fabiola, Dell'Eva, Raffaella, Esposito, Alessia, Generoso, Luca, Killian, Peter H., Mirisola, Valentina, Pfeffer, Ulrich, Romeo, Francesco   +9 more
core   +1 more source

Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining

Molecular Oncology, EarlyView.
IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis, Jack V. Mills, Wojciech Niedzwiedz, Valentine M. Macaulay   +3 more
wiley   +1 more source

The Level of C-Reactive Protein in the Blood Plasma of Young Adults with Childhood-Onset Growth Hormone Deficiency

Mìžnarodnij Endokrinologìčnij Žurnal, 2016
The article presents the data on the level of high-sensitivity C-reactive protein in the blood plasma of young adults with growth hormone deficiency that occurred in childhood and persists in adulthood.
O.V. Bolshova, T.O. Tkachova, O.A. Vyshnevska   +2 more
doaj   +1 more source

dUTPase is essential in zebrafish development and possesses several single‐nucleotide variants with pronounced structural and functional consequences

FEBS Open Bio, EarlyView.
dUTPases are involved in balancing the appropriate nucleotide pools. We showed that dUTPase is essential for normal development in zebrafish. The different zebrafish genomes contain several single‐nucleotide variations (SNPs) of the dut gene. One of the dUTPase variants displayed drastically lower protein stability and catalytic efficiency as compared ...
Viktória Perey‐Simon, Angéla Békesi, Latifa Kazzazy, Jázmin Mihály, Máté Varga, Beáta G. Vértessy, Kinga Nyíri   +6 more
wiley   +1 more source

Investigating prostate cancer tumour-stroma interactions - clinical and biological insights from an evolutionary game [PDF]

, 2011
BACKGROUND: Tumours are made up of a mixed population of different types of cells that include normal structures as well as ones associated with the malignancy, and there are multiple interactions between the malignant cells and the local ...
Alexander R. A. Anderson, David Basanta, Gustavo E. Ayala, Jacob G. Scott, Mayer N. Fishman, Simon W. Hayward   +5 more
core   +3 more sources

Dihydroorotate dehydrogenase (DHODH) regulates trophoblast syncytialization through organelle stress–induced cellular senescence

FEBS Open Bio, EarlyView.
The inhibition of mitochondrial dihydroorotate dehydrogenase (DHODH) impairs syncytialization and induces cellular senescence via mitochondrial and endoplasmic reticulum stress in human trophoblast stem cells, elevating sFlt1/PlGF levels, a hallmark of placental dysfunction in hypertensive disorders of pregnancy.
Kanoko Yoshida, Kazuya Kusama, Ayaka Horiuchi, Yu Kawaguchi, Atsuya Tsuru, Mikihiro Yoshie, Kazuhiro Tamura   +6 more
wiley   +1 more source

Current state of growth hormone therapy

مجله دانشگاه علوم پزشکی گرگان, 2003
Biosynthetic growth hormone is now available in virtually unlimited quantities. As a result because of its growth promoting and anabolic effects, it is widely used in various disorders in both children and adults.
S.Mohammandian (M.D), HR.Bazrafshan (M.D), A.Sadeghi-Nejad (M.D)   +2 more
doaj  

Efficacy and Safety of Growth Hormone (GH) Therapy in Patients with SHOX Gene Variants

Children
Background: Among the potential indications for growth hormone (GH) therapy is the presence of mutations in the SHOX (short stature homeobox-containing) gene, located in the telomeric pseudotautosomal region (PAR1) on the short arm of both sex ...
Giorgio Sodero, Federica Arzilli, Elena Malavolta, Marilea Lezzi, Fabio Comes, Antonietta Villirillo, Donato Rigante, Clelia Cipolla   +7 more
doaj   +1 more source