Results 121 to 130 of about 9,724,101 (403)

Combined Treatment with MEK and mTOR Inhibitors is Effective in In Vitro and In Vivo Models of Hepatocellular Carcinoma. [PDF]

, 2019
Background: Hepatocellular carcinoma (HCC) is the most common primary liver cancer histotype, characterized by high biological aggressiveness and scarce treatment options.
Calvisi, Diego F, Che, Li, Chen, Xin, Evert, Matthias, Hu, Junjie, Liu, Xianqiong, Lu, Xinjun, Song, Xinhua, Su, Tao, Utpatel, Kirsten, Wang, Jingxiao, Wang, Pan, Xu, Meng, Zhang, Jie, Zhang, Yi   +14 more
core   +1 more source

Peptide‐based ligand antagonists block a Vibrio cholerae adhesin

FEBS Letters, EarlyView.
The structure of a peptide‐binding domain of the Vibrio cholerae adhesin FrhA was solved by X‐ray crystallography, revealing how the inhibitory peptide AGYTD binds tightly at its Ca2+‐coordinated pocket. Structure‐guided design incorporating D‐amino acids enhanced binding affinity, providing a foundation for developing anti‐adhesion therapeutics ...
Mingyu Wang, Grace Du, Charity Yongo‐Luwawa, Angelina Lu, Brett Kinrade, Kim Munro, Karl E. Klose, William D. Lubell, Peter Davies, Shuaiqi Guo   +9 more
wiley   +1 more source

Integrative genome-wide analysis reveals the role of WIP proteins in inhibition of growth and development [PDF]

, 2020
Maria Victoria Gómez Roldán, Farhaj Izhaq, Marion Verdenaud, John Saviour Yaw Eleblu, Aimen Haraghi, Vivien Sommard, Pierre Chambrier, David Latrasse, Teddy Jégu, Moussa Benhamed, Judit Szécsi, Mohammed Bendahmane, Adnane Boualem, Abdelhafid Bendahmane   +13 more
openalex   +1 more source

Cardiac hypertrophy is inhibited by a local pool of cAMP regulated by phosphodiesterase 2 [PDF]

, 2015
Rationale: Chronic elevation of 3'-5'-cyclic adenosine monophosphate (cAMP) levels has been associated with cardiac remodelling and cardiac hypertrophy.
Aronsen, Jan M., Baillie, George S., Corsetti, Veronica, Dodoni, Giuliano, Fields, Laura A., Furlan, Leonardo, Gesellchen, Frank, Graham, Delyth, Hamilton, Graham M., Jiang, He, Krall, Judith, Lefkimmiatis, Konstantinos, Livie, Craig, Mancuso, Luisa, Movsesian, Matthew, Nicklin, Stuart A., Sin, Yuan Yan, Sjaastad, Ivar, Stangherlin, Alessandra, Surdo, Nicoletta C., Szabo-Fresnais, Nicolas, Terrin, Anna, Vandeput, Fabrice, Zaccolo, Manuela, Zoccarato, Anna   +24 more
core   +1 more source

PIF3 Is Involved in the Primary Root Growth Inhibition of Arabidopsis Induced by Nitric Oxide in the Light

Molecular Plant, 2013
SUMMARY Nitric oxide (NO) promotes the accumulation of PHYB and thus reduces PIF3. The activity of PIF3 was also regulated by RGL3. PIF3 may lie downstream of PHYB and RGL3, and regulate NO-induced root growth inhibition of Arabidopsis seedlings in light.
Sulan Bai, Tao Yao, Miaomiao Li, Xiaomin Guo, Yaochuan Zhang, Shengwei Zhu, Yi-kun He   +6 more
semanticscholar   +1 more source

Real‐time assay of ribonucleotide reductase activity with a fluorescent RNA aptamer

FEBS Letters, EarlyView.
Ribonucleotide reductases (RNR) synthesize DNA building blocks de novo, making them crucial in DNA replication and drug targeting. FLARE introduces the first single‐tube real‐time coupled RNR assay, which enables isothermal tracking of RNR activity at nanomolar enzyme levels and allows the reconstruction of allosteric regulatory patterns and rapid ...
Jacopo De Capitani, Noemi E. Nwosu, Viktoria Gocke, Müge Kasanmascheff, Hannes Mutschler   +4 more
wiley   +1 more source

Seed Germination-Influencing Bioactive Secondary Metabolites Secreted by the Endophyte Cladosporium cladosporioides LWL5

Molecules, 2013
The present study was aimed to isolate bioactive metabolites produced by a fungal endophyte from Helianthus annuus, Capsicum annuum, and Cucumis sativus and to assess their role in seed germination. Culture filtrate of the endophyte HA-3B from H. annuus
Muhammad Waqas, Abdul Latif Khan, Liaqat Ali, Sang-Mo Kang, Yoon-Ha Kim, In-Jung Lee   +5 more
doaj   +1 more source

Supplementary Figure 7 from Inhibition of Glutaminase Preferentially Slows Growth of Glioma Cells with Mutant IDH1 [PDF]

, 2023
Meghan J. Seltzer, Bryson D. Bennett, Avadhut D. Joshi, Ping Gao, Ajit G. Thomas, Dana Ferraris, Takashi Tsukamoto, Camilo Rojas, Barbara S. Slusher, Joshua D. Rabinowitz, Chi V. Dang, Gregory J. Riggins   +11 more
openalex   +1 more source

Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing

FEBS Letters, EarlyView.
Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley   +1 more source

Serum From Melioidosis Survivors Diminished Intracellular Burkholderia pseudomallei Growth in Macrophages: A Brief Research Report

Frontiers in Cellular and Infection Microbiology, 2020
Melioidosis is a neglected tropical disease with high mortality rate. It is caused by the Gram-negative, CDC category B select agent Burkholderia pseudomallei (B. ps) that is intrinsically resistant to first-line antibiotics. An antibody-based vaccine is
Panjaporn Chaichana, Barbara Kronsteiner, Barbara Kronsteiner, Patpong Rongkard, Prapit Teparrukkul, Direk Limmathurotsakul, Direk Limmathurotsakul, Direk Limmathurotsakul, Narisara Chantratita, Narisara Chantratita, Nicholas P. J. Day, Nicholas P. J. Day, Helen A. Fletcher, Susanna J. Dunachie, Susanna J. Dunachie, Susanna J. Dunachie   +15 more
doaj   +1 more source