Growth Inhibition of a Yeast by Uracil, and its Reversal by Arginine [PDF]
, 1950 E. J. Miller, Joseph S. Harrison
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Imeglimin attenuates liver fibrosis by inhibiting vesicular ATP release from hepatic stellate cells
FEBS Letters, EarlyView.Imeglimin, at clinically relevant concentrations, inhibits vesicular ATP accumulation and release from hepatic stellate cells, thereby attenuating purinergic signaling and reducing fibrogenic activation. This mechanism reveals a newly identified antifibrotic action of imeglimin beyond glycemic control.
Seiji Nomura +8 more
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The Effect of Several Compounds on the Inhibition of Bacterial Growth by Sulfaguanidine, Sulfamerazine, and Sulfasuxidine [PDF]
, 1948 W. E. Clapper, Ikuya T. Kurita
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Inhibition of Bacterial Growth by Auxins
Experimental Biology and Medicine, 1946 We have observed that a number of synthetic unsaturated ring-containing acids endowed with auxin (plant hormone) activity can exert a bacteriostatic effect on the growth of certain bacterial species. The following substances were selected as representatives of different chemical types of auxins: indole-3-acetic acid, β-(indole-3)-propionic acid ...
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Cancer cell death induced by the NAD antimetabolite Vacor discloses the antitumor potential of SARM1
FEBS Letters, EarlyView.Vacor, a compound converted into the toxic metabolite Vacor adenine dinucleotide (VAD) by the nicotinamide salvage pathway enzymes NAMPT and NMNAT2, exhibits antitumor activity by inducing rapid and complete NAD depletion. We report that Vacor toxicity is limited to cell lines expressing high levels of SARM1, a NAD glycohydrolase.
Giuseppe Ranieri +5 more
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GROWTH INHIBITION OF EBERTHELLA TYPHOSA BY CERTAIN CARBOHYDRATES AND ITS RELEASE BY MUTATION [PDF]
, 1949 Ingebjorg Lid Barkulis
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RAD50 missense variants differentially affect the DNA damage response and mitotic progression
FEBS Letters, EarlyView.RAD50 incorporates into the MRN complex and initiates the DNA damage response. Furthermore, RAD50 promotes mitotic progression. RAD50 missense variants capable of forming an MRN complex supported the DNA damage response and mitotic features to different extents in complementation experiments, indicating these functions are separable and might impact ...
Hanna Redeker +9 more
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Selective endothelial growth inhibition by tetracyclines that inhibit collagenase
Biochemical and Biophysical Research Communications, 1992 The potential of angiogenesis inhibitors as therapy for human diseases is limited by a lack of clinically available agents. We investigated the mechanism of the anti-angiogenesis effects of minocycline, a commonly used drug, and several derivatives. Endothelial cell proliferation was inhibited by several of these compounds. We found that inhibition was
Taras Masnyk +5 more
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Overcoming myelosuppression due to synthetic lethal toxicity for FLT3-targeted acute myeloid leukemia therapy. [PDF]
, 2014 Activating mutations in FLT3 confer poor prognosis for individuals with acute myeloid leukemia (AML). Clinically active investigational FLT3 inhibitors can achieve complete remissions but their utility has been hampered by acquired resistance and ...
He, Bai-Liang +9 more
core
Molecular Oncology, EarlyView.There is an unmet need in metastatic breast cancer patients to monitor therapy response in real time. In this study, we show how a noninvasive and affordable strategy based on sequencing of plasma samples with longitudinal tracking of tumour fraction paired with a statistical model provides valuable information on treatment response in advance of the ...
Emma J. Beddowes +20 more
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