Results 331 to 340 of about 9,724,101 (403)

FIGURE 6 from Inhibition of PRL2 Upregulates PTEN and Attenuates Tumor Growth in <i>Tp53</i>-deficient Sarcoma and Lymphoma Mouse Models

Frederick Nguele Meke, Yunpeng Bai, Diego Ruiz-Avila, Colin Carlock, Jinan Ayub, Jinmin Miao, Yanyang Hu, Qinglin Li, Zhong‐Yin Zhang   +8 more
openalex   +1 more source

Rethinking plastic waste: innovations in enzymatic breakdown of oil‐based polyesters and bioplastics

FEBS Open Bio, EarlyView.
Plastic pollution remains a critical environmental challenge, and current mechanical and chemical recycling methods are insufficient to achieve a fully circular economy. This review highlights recent breakthroughs in the enzymatic depolymerization of both oil‐derived polyesters and bioplastics, including high‐throughput protein engineering, de novo ...
Elena Rosini, Nicolò Antonelli, Gianluca Molla   +2 more
wiley   +1 more source

Comprehensive profiling of RNA modification-related genes identifies RNA m⁷G binding protein CBP20 as a therapeutic target for tumor growth inhibition. [PDF]

Exp Mol Med
Cho Y, Lee SE, Oh J, Jang D, Shin S, Lee SJ, Kim J, Yang Y, Kim D, Jung HR, Oh Y, Park YB, Choi JM, Cho SY.   +13 more
europepmc   +1 more source

Phytochemistry, Pharmacology, and Growth-Inhibition Effects of Euphorbia Tirucalli, a Medicinal Plant in Tanzania's Semi-Arid Areas

Hamisi Yunus Nchimbi
openalex   +1 more source

Homologous expression and purification of human HAX‐1 for structural studies

FEBS Open Bio, EarlyView.
This research protocol provides detailed instructions for cloning, expressing, and purifying large quantities of the intrinsically disordered human HAX‐1 protein, N‐terminally fused to a cleavable superfolder GFP, from mammalian cells. HAX‐1 is predicted to undergo posttranslational modifications and to interact with membranes, various cellular ...
Mariana Grieben
wiley   +1 more source

FL496, an FL118-derived small molecule, induces growth inhibition, senescence, and apoptosis of malignant pleural mesothelioma (MPM) cells, and exhibits anti-MPM tumor efficacy strikingly superior to the pemetrexed-cisplatin combination. [PDF]

J Exp Clin Cancer Res
Aljahdali IAM, Ling X, Wu W, Wang W, Li D, Zhang R, Zhang E, Stablewski A, Azrak R, Li Q, Li F.   +10 more
europepmc   +1 more source

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Day/night variations of myeloid and lymphoid cell subsets in the murine inguinal lymph node

FEBS Open Bio, EarlyView.
The circadian system is involved in the temporal regulation of the immune system. Our study reveals that two innate immune populations, NKT cells and neutrophils, predominate at the beginning of the day in healthy mice, highlighting how the time of day influences immune responses.
Paula M. Wagner, César G. Prucca, Lucia Boffelli, Virginia A. Piqueras, Silvia G. Correa, Mariana Maccioni, Mario E. Guido   +6 more
wiley   +1 more source

Imipramine-induced immunomodulation and intracellular growth inhibition during <i>Brucella abortus</i> 544 infection in RAW 264.7 cells and BALB/c mice. [PDF]

Front Vet Sci
Aguilar CNT, Huy TXN, Nguyen TT, Salad SA, Cho SE, Hong IH, Min W, Lee HJ, Kim S.   +8 more
europepmc   +1 more source

ATG4B is required for mTORC1‐mediated anabolic activity and is associated with clinical outcomes in non‐small cell lung cancer

FEBS Open Bio, EarlyView.
The relationship between anabolic and catabolic processes governing lung cancer cell growth is nuanced. We show that ATG4B, an autophagy regulator, is elevated in lung cancer and that high ATG4B is associated with worse patient outcomes. Targeting ATG4B in cells reduces growth, protein synthesis, and mTORC1 activity, demonstrating a new relationship ...
Patrick J. Ryan, Bethany C. Guerra, Selina Uranga, Jessica M. Cardin, Steven E. Riechman, Mariana Janini Gomes, James D. Fluckey   +6 more
wiley   +1 more source