Results 281 to 290 of about 1,482,290 (356)

The cooperative regulation of miR‐221 by APE1 and AUF1 impacts p27Kip1 defining a miR signature relevant for cervical cancer

FEBS Open Bio, EarlyView.
A regulatory axis involving APE1, AUF1, and miR‐221 is proposed. Pri‐miR‐221 is processed by DROSHA and DICER to generate mature miR‐221, which targets p27Kip1 mRNA. APE1 and AUF1 compete for pre‐miR‐221 binding. Reduced APE1/AUF1 levels impair miR‐221 biogenesis, decrease p27Kip1 mRNA degradation, and promote cell cycle progression, chemoresistance ...
Matilde Clarissa Malfatti, Nicolò Gualandi, Gianluca Tell, Giulia Antoniali   +3 more
wiley   +1 more source

Downregulation of B7-H4 contributes to the synergistic effect of USP2a-targeted/anti-PD-1 combination therapy in EGFR mutant lung cancer. [PDF]

Cancer Immunol Immunother
Sun B, Kong M, Jiang X, Zhu L, Zhang J, Tan L, Wang C, Yuan Z, Chen S, Wang C, Jiang Y, Zhang L.   +11 more
europepmc   +1 more source

Dapagliflozin prevents methylglyoxal‐induced retinal cell death in ARPE‐19 cells

FEBS Open Bio, EarlyView.
Diabetic macular oedema is a diabetes complication of the eye, which may lead to permanent blindness. ARPE‐19 are human retinal cells used to study retinal diseases and potential therapeutics. Methylglyoxal is a compound increased in uncontrolled diabetes due to elevated blood glucose.
Naina Trivedi, Zainab Quraishi, Shima Khezri Azizi Far, Madaleine Ward, Aidan Conway, Reem Abdulredha, Eman Mshari, Yousif A. Shamsaldeen   +7 more
wiley   +1 more source

Key Considerations for Targeting <i>KRAS</i> in Pancreatic Cancer: Potential Impact on the Treatment Paradigm. [PDF]

Drug Des Devel Ther
Eslinger C, Sonbol MB, George B, Babiker H, Borad MJ, Bekaii-Saab TS.   +5 more
europepmc   +1 more source

Nuclear pore links Fob1‐dependent rDNA damage relocation to lifespan control

FEBS Open Bio, EarlyView.
Damaged rDNA accumulates at a specific perinuclear interface that couples nucleolar escape with nuclear envelope association. Nuclear pores at this site help inhibit Fob1‐induced rDNA instability. This spatial organization of damage handling supports a functional link between nuclear architecture, rDNA stability, and replicative lifespan in yeast.
Yamato Okada, Mina Iwaki, Kyosuke Hagiri, Rei Izumi, Masahiko Harata, Chihiro Horigome   +5 more
wiley   +1 more source

Growth Regulating Substances in Extracts of Maple and Pear Flower Buds [PDF]

, 1958
Bailey, Lowell F., Tackett, Dewey L.
core   +2 more sources

Single-Cell Lineage Tracing Uncovers Resistance Signatures and Sensitizing Strategies to FLT3 Inhibitors in Acute Myeloid Leukemia. [PDF]

Cancer Res
Eriksson J, Zheng S, Popa M, Bao J, Dai J, Wang W, McCormack E, Vähärautio A, Tang J.   +8 more
europepmc   +1 more source

A different MAPK, ERK5 plays a critical role in cell specification and differentiation. [PDF]

Biochem Biophys Rep
Li J, Hou X, Li X, Ji S.
europepmc   +1 more source

Strategic selection of MDM2 inhibitors enhances the efficacy of FAK inhibition in mesothelioma based on TP53 genotype. [PDF]

PLoS One
Ning X, Nguyễn TTT, Morinaga T, Tada Y, Shimada H, Hiroshima K, Yamaguchi N, Tagawa M.   +7 more
europepmc   +1 more source

Poncirin Impact on Human HER2 Breast Cancer Cells: Inhibiting Proliferation, Metastasis, and Tumor Growth in Mice Potentially through The PI3K/AKT Pathway.

Yun Hao, Jing Li, Jinwen Zhou, Yuanwei Liu, Jin Zhang   +4 more
openalex   +2 more sources