Results 1 to 10 of about 2,863,830 (263)

The interplay between obesity and cancer: a fly view

Disease Models & Mechanisms, 2016
Accumulating epidemiological evidence indicates a strong clinical association between obesity and an increased risk of cancer. The global pandemic of obesity indicates a public health trend towards a substantial increase in cancer incidence and mortality.
Susumu Hirabayashi
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Non-human primate preclinical model revealed the feasibility and short-term safety of iPSC-derived innate-like T cells in autologous transplantation

Frontiers in Immunology
BackgroundT cells derived from gene-edited induced pluripotent stem cells (iPSCs) are a promising alternative cell source for universal T-cell immunotherapy.
Yasuyuki Miyake, Shoichi Iriguchi, Ai Kawana-Tachikawa, Shuichi Kitayama, Eri Imai, Kahoru Taya, Hiroshi Ishii, Tomoyuki Miura, Hiromi Sakawaki, Tetsuro Matano, Tetsuro Matano, Shin Kaneko   +11 more
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NAMPT as a Dedifferentiation-Inducer Gene: NAD+ as Core Axis for Glioma Cancer Stem-Like Cells Maintenance

Frontiers in Oncology, 2019
Glioma Cancer Stem-Like Cells (GSCs) are a small subset of CD133+ cells with self-renewal properties and capable of initiating new tumors contributing to Glioma progression, maintenance, hierarchy, and complexity.
Antonio Lucena-Cacace, Masayuki Umeda, Lola E. Navas, Lola E. Navas, Amancio Carnero, Amancio Carnero   +5 more
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Cell growth and cell cycle control

Molecular Biology of the Cell, 2013
mbc.E13-01-0002 Molecular Biology of the Cell Volume 24 Page 678 MBoC is pleased to publish this summary of the Minisymposium “Cell Growth and Cell Cycle Control” held at the American Society for Cell Biology 2012 Annual Meeting, San Francisco, CA, December 19, 2012.
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Identification of Cardiomyocyte-Fated Progenitors from Human-Induced Pluripotent Stem Cells Marked with CD82

Cell Reports, 2018
Summary: Here, we find that human-induced pluripotent stem cell (hiPSC)-derived cardiomyocyte (CM)-fated progenitors (CFPs) that express a tetraspanin family glycoprotein, CD82, almost exclusively differentiate into CMs both in vitro and in vivo. CD82 is
Masafumi Takeda, Yasuharu Kanki, Hidetoshi Masumoto, Shunsuke Funakoshi, Takeshi Hatani, Hiroyuki Fukushima, Akashi Izumi-Taguchi, Yusuke Matsui, Teppei Shimamura, Yoshinori Yoshida, Jun K. Yamashita   +10 more
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Interferons and cell growth control.

Histology and histopathology, 2000
Cytokines modulate cell growth, differentiation, and immune defenses in the vertebrates. Interferons (IFNs) are a unique class of cytokines that stimulate antiviral, antitumor and antigen presentation by inducing the expression of several cellular genes. Recent studies have identified a novel gene regulatory pathway activated by IFNs, which serves as a
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Development of chimeric antigen receptor T cells targeting cancer-expressing podocalyxin

Regenerative Therapy
Chimeric Antigen Receptor (CAR)-T cell therapy has revolutionized the treatment of CD19-positive B-cell malignancies. However, the field is rapidly evolving to target other antigens, such as podocalyxin (PODXL), a transmembrane protein implicated in ...
Yuta Mishima, Shintaro Okada, Akihiro Ishikawa, Bo Wang, Masazumi Waseda, Mika K. Kaneko, Yukinari Kato, Shin Kaneko   +7 more
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CSMA: A Standalone and ImageJ-Compatible Tool for Enhanced Wound Healing Assay Analysis

IEEE Access
Accurate quantification of wound closure in cell migration assays is crucial yet challenging. Still, existing methods often underperform due to omitting cell detection within the wound area, resulting in biased outcomes.
Tri Thanh Pham, Amina Sagymbayeva, Timur Elebessov, Zhadyra Onzhanova, Ferdinand Molnar   +4 more
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Modeling of T cell-mediated autoimmune pituitary disease using human induced pluripotent stem cell-originated organoid

Nature Communications
Anti-pituitary-specific transcription factor (PIT)−1 hypophysitis is an autoimmune disease characterized by hormone secretion impairment from PIT-1-expressing pituitary cells, accompanied by malignancies with ectopic PIT-1 expression.
Keitaro Kanie, Takeshi Ito, Genzo Iguchi, Ryusaku Matsumoto, Keiko Muguruma, Shin Urai, Shuichi Kitayama, Hironori Bando, Masaaki Yamamoto, Hidenori Fukuoka, Wataru Ogawa, Shin Kaneko, Yutaka Takahashi   +12 more
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Integrative Transcriptomic-Histological Analysis in Dilated Cardiomyopathy Unveils FGFR1 Inhibition as Anti-Cardiac Fibrotic and Cardioprotective Therapy

JACC: Basic to Translational Science
Summary: Cardiac fibrosis drives dysfunction in dilated cardiomyopathy (DCM); yet, effective therapies are limited. This study identifies FGFR1 as a critical target in cardiac fibrosis using transcriptomic and histological analyses of 58 human DCM ...
Reo Hata, MD, Shunsuke Funakoshi, MD, PhD, Takeru Makiyama, MD, PhD, Takao Kato, MD, PhD, Megumi Narita, BS, Yasuko Matsumura, MS, Ryoko Hirohata, MS, Yuki Naka, BS, Kazumi Ida, MS, Hiroaki Ito, MD, Akihiko Yoshizawa, MD, PhD, Yasuhito Nannya, MD, PhD, Hironori Haga, MD, PhD, Seishi Ogawa, MD, PhD, Koh Ono, MD, PhD, Takeshi Kimura, MD, PhD, Yoshinori Yoshida, MD, PhD   +16 more
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