Results 31 to 40 of about 14,501,441 (297)

Generation of Scaffoldless Hyaline Cartilaginous Tissue from Human iPSCs

Stem Cell Reports, 2015
Defects in articular cartilage ultimately result in loss of joint function. Repairing cartilage defects requires cell sources. We developed an approach to generate scaffoldless hyaline cartilage from human induced pluripotent stem cells (hiPSCs).
Akihiro Yamashita, Miho Morioka, Yasuhito Yahara, Minoru Okada, Tomohito Kobayashi, Shinichi Kuriyama, Shuichi Matsuda, Noriyuki Tsumaki   +7 more
doaj   +1 more source

Podoplanin as an Attractive Target of CAR T Cell Therapy

Cells, 2020
To date, various kinds of cancer immunotherapy methods have been developed, but T cell immunotherapy is one of the most promising strategies. In general, T cell receptor (TCR) or chimeric antigen receptor (CAR) is used to modify the antigen specificity ...
Masazumi Waseda, Shin Kaneko
doaj   +1 more source

SPHINX31 acts as a SRPK1 inhibitor targeting the ATR/DNA‐PKcs/CHK1 replicative checkpoint to inhibit cell growth in non‐small cell lung cancer [PDF]

Molecular Oncology, EarlyView.
The kinase SRPK1 directly interacts with the protein TOPBP1 and regulates the pre‐mRNA splicing of WIZ thereby contributing to the activation of the ATR/CHK1 replicative checkpoint in response to replicative stress. This allows cancer cells' genomic stability and survival.
Amani Shreim, Aurelie Genoux, Nadiia Zubchuk, Haoyang Zheng, Perla Salameh, Theo Ziegelmeyer, Fabien Dalonneau, Margot Rouchette, Christiane Oddou, Simona Miron, Helene Polveche, Adiilah Mamode Cassim, Carmen Garrido, Eleni Nikolakaki, Didier Auboeuf, Tao Jia, Sophie Zinn‐Justin, Beatrice Eymin   +17 more
wiley   +2 more sources

Stem cell growth and differentiation in Hydra attenuata [PDF]

, 1979
Interstitial stem cells in Hydra are rapidly proliferating multipotent stem cells which continuously give rise to precursors for nerve and nematocyte differentiation.
Sproull, Frederick, David, Charles N.
core   +1 more source

Growth modification : what works, what doesn't, and why

, 1999
http://babel.hathitrust.org/cgi/pt?id=mdp.39015046466275;view=2up;ui=fullscreen#page/n0/mode ...
Symposium on Craniofacial Growth
core   +7 more sources

Coupling the cell cycle to cell growth [PDF]

The EMBO Reports, 2003
In order to multiply, both prokaryotic and eukaryotic cells go through a series of events that are collectively called the cell cycle. However, DNA replication, mitosis and cell division may also be viewed as having their own, in principle independent, cycles, which are tied together by mechanisms extrinsic to the cell cycle--the checkpoints--that ...
Erik, Boye, Kurt, Nordström
openaire   +2 more sources

Generation of macrophages with altered viral sensitivity from genome-edited rhesus macaque iPSCs to model human disease

Molecular Therapy: Methods & Clinical Development, 2021
Because of their close biological similarity to humans, non-human primate (NHP) models are very useful for the development of induced pluripotent stem cell (iPSC)-based cell and regenerative organ transplantation therapies.
Yoshihiro Iwamoto, Yohei Seki, Kahoru Taya, Masahiro Tanaka, Shoichi Iriguchi, Yasuyuki Miyake, Emi E. Nakayama, Tomoyuki Miura, Tatsuo Shioda, Hirofumi Akari, Akifumi Takaori-Kondo, Shin Kaneko   +11 more
doaj   +1 more source

Cell Wall Layer Induced in Xylem Fibers of Flax Upon Gravistimulation Is Similar to Constitutively Formed Cell Walls of Bast Fibers

Frontiers in Plant Science, 2021
In the fibers of many plant species after the formation of secondary cell walls, cellulose-enriched cell wall layers (often named G-layers or tertiary cell walls) are deposited which are important in many physiological situations.
Anna Petrova, Liudmila Kozlova, Oleg Gorshkov, Alsu Nazipova, Marina Ageeva, Tatyana Gorshkova   +5 more
doaj   +1 more source

Immune synapse molecules knockout in induced pluripotent stem cells enables broad NK cell resistance in T cell progeny

Regenerative Therapy
Introduction: Allogeneic iPSCs provide a potential source for regenerative T cell therapies, yet their clinical application remains limited by immune rejection driven by human leukocyte antigen (HLA) incompatibility.
Jing Zhang, Keisuke Sumide, Keitaro Kanie, Akihiro Ishikawa, Munehiro Yoshida, Tomoko Ishii, Bo Wang, Shin Kaneko   +7 more
doaj   +1 more source

Effective and stable gene transduction in rhesus macaque iPSCs capable of T-lineage differentiation utilizing the piggyBac system

Regenerative Therapy
Introduction: Genetically modified human induced pluripotent stem cell (iPSC)-based regenerative medicine has substantial potential in the treatment of refractory human diseases.
Masahiro Tanaka, Yoshihiro Iwamoto, Bo Wang, Eri Imai, Munehiro Yoshida, Shoichi Iriguchi, Shin Kaneko   +6 more
doaj   +1 more source