Results 141 to 150 of about 8,355,585 (278)

Spatial and single‐nuclei transcriptomics reveals idiosyncratic and generic patterns in papillary and anaplastic thyroid cancers

Molecular Oncology, EarlyView.
Matched spatial transcriptomics and single‐nuclei RNA‐seq were generated for anaplastic and BRAFV600E papillary thyroid cancers revealing generic and tumor‐specific states occurring in cancer cells and in the tumor microenvironment. In this context, cancer dedifferentiation mirrored organoid maturation through ordered thyroid marker gain/loss ...
Adrien Tourneur, Joel Rodrigues Vitória, Manuel Saiselet, Ligia Craciun, Denis Larsimont, Anne Lefort, Frédérick Libert, Carine Maenhaut, Sabine Costagliola, Maxime Tarabichi, Mirian Romitti, Vincent Detours   +11 more
wiley   +1 more source

Re-examining the iron paradox: the influence of growth medium on regulation and functionality of the tropodithietic acid (TDA) biosynthetic pathway in Phaeobacter piscinae. [PDF]

FEMS Microbiol Ecol
Alfastsen L, Mauduit M, Cowled MS, Vig NA, Friis-Møller R, Reimert FVH, Schostag MD, Andersen AJC, Gram L, Zhang SD.   +9 more
europepmc   +1 more source

Effects of Growth Medium and Inoculum Size on Pharmacodynamics Activity of Marbofloxacin against Staphylococcus aureus Isolated from Caprine Clinical Mastitis. [PDF]

Antibiotics (Basel), 2021
Lorenzutti AM, San Andrés-Larrea MI, Fernández-Varón E, Zarazaga MDP, Molina-López AM, Serrano-Rodríguez JM.   +5 more
europepmc   +1 more source

Inhibition of cyclin‐dependent kinases 12/13 using CT7439 as a treatment for colorectal cancer with CDK12 upregulation

Molecular Oncology, EarlyView.
The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington, Divya L. Dayanidhi, Mohammad Zokaasadi, John B. Mantyh, Pelumi D. Olawuni, Gabrielle Rupprecht, Jeremy M. Force, Shannon McCall, Ashwani K. Bahl, David S. Hsu, Jason A. Somarelli   +10 more
wiley   +1 more source

¹H-NMR-Based Metabolomic Study of Tomato Cultivars, Heinz and Roma, Grown on Selected Growth Medium and Deep-Water Hydroponic Culture System. [PDF]

Metabolites
Nsele SN, Raletsena MV, Ogugua UV, Adriaanse P.   +3 more
europepmc   +1 more source

Stability studies with tigecycline in bacterial growth medium and impact of stabilizing agents. [PDF]

Eur J Clin Microbiol Infect Dis, 2021
Amann LF, Vicente ER, Rathke M, Broeker A, Riedner M, Wicha SG.   +5 more
europepmc   +1 more source

Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology

Molecular Oncology, EarlyView.
This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic, Maria Concetta Vitale, Rita Siino, Emilia Di Giovanni, Carla Ferrante Bannera, Enrico Di Marco, Andrea Gottardo, Tancredi Didier Bazan Russo, Nadia Barraco, Alessandro Perez, Valerio Gristina, Antonio Galvano, Giuseppe Badalamenti, Antonio Russo, Viviana Bazan, Lorena Incorvaia   +15 more
wiley   +1 more source

Improving growth and lipid accumulation in a novel oleaginous fungus Fusarium solani as a promising feedstock for biodiesel: optimization of growth medium and fatty acid characterization. [PDF]

BMC Microbiol
Hassan SHA, Fawzy MA, Sonbol H, Alsaloom AN, Koutb M, Ibrahim AG.   +5 more
europepmc   +1 more source

An optimized growth medium for increased recombinant protein secretion titer via the type III secretion system. [PDF]

Microb Cell Fact, 2021
Burdette LA, Wong HT, Tullman-Ercek D.
europepmc   +1 more source

Preoperative circulating tumor cells integrated with imaging analysis for prognostic evaluation in head and neck squamous cell carcinoma

Molecular Oncology, EarlyView.
Detecting circulating tumor cells (CTCs) in blood before surgery may help predict outcomes in patients with head and neck squamous cell carcinoma (HNSCC). Here, we show when combined with tumor size and lymph node involvement from routine imaging, CTC status identifies high‐risk patients with poorer survival—offering a simple, minimally invasive tool ...
Susanne Flach, Gizem Abaci, Tom Huberty, Axel Lechner, Lukas Käsmann, Jens Ricke, Sophia Stöcklein, Martin Canis, Philipp Baumeister, Marianna Alunni‐Fabbroni   +9 more
wiley   +1 more source