Results 41 to 50 of about 365,945 (264)

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Peran Growth Opportunities, Free Cash Flow, dan Relative Issue Size dalam Reaksi Pasar terhadap Pengumuman Right Issue

Journal the Winners, 2007
Right issue is when a firm announces its plan to publicly offer additional shares of common stock after Initial Public Offering (IPO). The aim of this research are to test market stock price and examine the role of growth opportunities in stock price ...
Synthia Atas Sari, Hartiwi Prabowo
doaj   +1 more source

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

FEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil, Anna Corrà, Annalisa Scapolatiello, Chengxiang Qiu, Gianluca Amadei   +4 more
wiley   +1 more source

Pengaruh Life-Cycle Perusahaan terhadap Incremental Value-Relevance Informasi Laba

Journal of Accounting and Investment, 2016
The main objective of this paper is to examine the effect of life-cycle of firm on the relationship between earnings information and market value of equity. This research is based on inconsistency of the result previous research. I derive hypothesis from
Abd. Hamid Habbe
doaj  

Investigating the Effect of Capital Structure and Growth Opportunities on Earnings Management [PDF]

International Journal of Management, Accounting and Economics, 2015
The main goal of this study is to investigate the effect of capital structure and growth opportunities on earnings management in companies accepted in Tehran securities exchange during 2008 to 2013.
Mahmoud Nozarpour, Hamid Norouzi
doaj  

From mice to humans—divergent strategies for intestinal homeostasis and regeneration

FEBS Letters, EarlyView.
Recent advances such as organoid genome editing, xenotransplantation, imaging, and whole‐genome sequencing have enabled direct studies of human intestinal stem cells (ISCs). These studies reveal species‐specific features, including slower ISC proliferation, distinct injury responses, slower somatic mutation accumulation in humans, and an inverse ...
Keiko Ishikawa, Shinya Sugimoto, Toshiro Sato   +2 more
wiley   +1 more source

The Investigation of the Relationship Between Growth Type and Capital Structure of Firms [PDF]

راهبرد مدیریت مالی, 2016
The purpose of this study was to investigation the relationship between growth type and capital structure of listed firms in Tehran Stock Exchange. For this purpose, the firms are classified in to three groups low, mix and high growth and statistical ...
Omid Pourheydari, Mohammad Hossein Vadiei Nowghabi, Rahmat Houshmand Zaferanie, Morteza Dehghani, Fateme Dehghan   +4 more
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Enhancing R&D investments through investment efficiency in multi-business firms: the roles of cash holdings and growth opportunities

Cogent Business & Management
This study examines the influence of investment efficiency on augmenting R&D investment in multi-business firms, considering the moderating effects of cash holdings and growth opportunities.
Thi Bao Chau Nguyen, Quoc Nghi Nguyen
doaj   +1 more source