Results 161 to 170 of about 1,461,056 (318)

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Exploring Growth Pattern and Candidate Genes for Chicken Spur. [PDF]

Animals (Basel)
Yuan H, Liao Q, Yang Z, Zhang Z, Li J, Li F, Wang Y, Zhou B, Luo J, Yang X.   +9 more
europepmc   +1 more source

Heterozygous loss‐of‐function alleles associate the conserved 3′‐5′ exoribonuclease EXOSC10 with hypersensitivity to the anticancer drug 5‐fluorouracil

Molecular Oncology, EarlyView.
EXOSC10, an essential nuclear RNA exosome‐associated 3′‐5′ exoribonuclease, is inhibited by the anticancer drug 5‐fluorouracil (5‐FU), and EXOSC10 depletion increases 5‐FU sensitivity. The colon‐cancer variant EXOSC10S402T, located in a proteolysis motif, is stable and nuclear but nonfunctional in vivo.
Radhika Sain, Yann Le Page, Frédéric Percevault, Emmanuelle Becker, Luc Negroni, Almudena Fernandez, Marta Cantero, Diego Muñoz‐Santos, Lluís Montoliu, Cyrille Garnier, Michael Primig   +10 more
wiley   +1 more source

Spatiotemporal analysis of Indian megacities

, 2008
Urbanization is arguably the most dramatic form of highly irreversible land transformation. While urbanization is a worldwide phenomenon, it is exceptionally dynamic in India, where unprecedented urban growth rates have occurred over the last 30 years ...
Taubenböck, Hannes, Roth, Achim, Mehl, Harald, Berger, Christian, Wegmann, Martin, Breunig, Markus   +5 more
core  

Quantification of Craniofacial Growth Pattern Based on Deep Learning. [PDF]

Bioengineering (Basel)
Hu Z, Zhang Y, Liu N, Gao X, Huang Z, Wu G, Zhang Z, Wang S.   +7 more
europepmc   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Incidence, Bacterial Growth Pattern and Antibiotic Sensitivity of Patient With Pressure Ulcer in Dr.Soetomo General Hospital Surabaya [PDF]

: Pressure ulcer is a condition often found in chronically ill patients with prolonged immobilization. Infected pressure sore can inhibit wound healing, wound treatment and worsen the patient's condition.
Iswinarno Doso Saputro, Iswinarno, Kevin Andana H.S, Kevin, Damayanti, Damayanti   +2 more
core  

Growth Pattern and Condition in the Mudskipper <i>Scartelaos histophorus</i> in the Mekong Delta. [PDF]

Ecol Evol
Phan GH, Dinh QM, Nguyen THD.
europepmc   +1 more source

Hijacking emergency granulopoiesis: Neutrophil ontogeny and reprogramming in cancer

Molecular Oncology, EarlyView.
Neutrophils are highly plastic innate immune cells; their functions in cancer extend beyond the tumour microenvironment. This Review summarises current understanding of neutrophil maturation and heterogeneity and highlights tumour‐induced granulopoiesis as a systemic programme that expands immature, immunosuppressive neutrophils via tumour‐derived ...
Gabriela Marinescu, Yi Feng
wiley   +1 more source

Tobacco smoking is associated with solid growth pattern in primary lung adenocarcinoma. [PDF]

Discov Oncol
Blessing A, Csanadi A, Kayser C, Oberndorfer F, Kayser G.   +4 more
europepmc   +1 more source